To the Editor—It was with interest that we read the study by Frey et al. [1], which describes a randomized trial in which 3 manufacturing consistency lots of a combined hepatitis A and B vaccine were compared with the corresponding monovalent vaccines. The authors observed a nonsatisfactory response to the hepatitis B component in the combined vaccine. We are concerned that this report may be m...

background: the capacity of human hbaa erythrocytes of non-malarious blood to withstand osmotic stress in the presence of five antimalarial drugs, chloroquine phosphate, quinine, fansidartm, coartemtm and halfantm was studied in vitro. materials and methods: aqueous solutions of four increasing concentrations of the drugs used in this investigation were in the order: 0.2%, 0.4%, 0.6% and 0.8% (...

Editorial Adverse drug reaction of the month-a new series This issue of the Postgraduate Medical Journal sees the launch of a new series of articles, Adverse drug reaction of the month. The series has two objectives. First, it is intended to inform practising clinicians about significant adverse reactions (ADRs), as well as their diagnosis, management and prevention. Second, we unashamedly wish...

OBJECTIVE To evaluate the immunogenicity and reactogenicity of an acellular pertussis vaccine (pa) either formulated with diphtheria and tetanus toxoids (dTpa) or administered consecutively with a licensed tetanus and diphtheria vaccine (Td) as a 5th dose in adolescents. METHODS A total of 510 healthy children 10 to 13 years of age were assigned randomly, using a single-blind design, to recei...

BACKGROUND In 1992-1993, a randomized, double-blind, placebo-controlled clinical trial of two 3-component acellular pertussis vaccines was started in 4 of Italy's 20 regions. During the trial, the children had been randomized to receive 3 doses of 1 of 2 acellular pertussis vaccines combined with diphtheria and tetanus toxoids (DT) or of a DT vaccine only, at 2, 4, and 6 months of age. Both dip...

Traumatic dislocation ofthe hip with a fracture ofthe shaft ofthe femur on the same side is such a rare injury that, although there are several reports ofsingle patients, only two surgeons, Dehne and Immermann (1951), have reported treating a number ofpatients. Sir Astley Cooper in I 823 was the first to record the successful treatment of this condition. His patient, a boy of sixteen, had a fra...

The aim of this study was to compare pertussis-specific humoral and cellular immunity in children 5 years after a primary vaccination with a combined diphtheria, tetanus, tricomponent acellular pertussis, and hepatitis B vaccine (DTaP-HBV; InfanrixHepB; SmithKline Beecham) with immunity after natural infection. The subjects were 38 children aged 5 to 6 years who received DTaP-HBV at 3, 5, and 1...

Piperonal, once used co kill lice in Australian hospitals, was acclaimed as an effective pediculicide (Corlecce, 1925) by the standards ofthe day. It is unusual in also exhibiting a repellent actionagainstlice,apropertyonlyrecentlyrealisedAnew,easy to use, low-fragrance, pump action spray, which incorporates 1% piperonal, was tested in die laboratory using clothing lice in an arena cesc and was...

This paper examines the inter-relationship between crisis planning and management and ethical decision making processes and practices as an example of building an interdisciplinary approach to crisis planning. The actions of the key organisations involved in the recent pharmaceutical product tampering cases in Australia are used to explore how responses during crisis correspond to both classica...