نتایج جستجو برای: hairy cell leukemia
تعداد نتایج: 1774810 فیلتر نتایج به سال:
Hairy cell leukemia (HCL) is a relatively rare, chronic B-cell lymphoproliferative disorder characterized by splenomegaly, pancytopenia and bone marrow infiltration by hairy cells with circumferential prominent hairy cytoplasmic projections. Splenomegaly with few atypical lymphoid cells in peripheral blood lead to the examination of bone marrow for morphological findings characteristic of hairy...
BACKGROUND We previously reported ongoing mutational and isotype switch events in the immunoglobulin (Ig) heavy chain (H) locus in hairy cell leukemia. Those analyses raised questions on the incidence and type of selective influences occurring on the tumor B-cell receptor of hairy cell leukemia. DESIGN AND METHODS To further investigate this issue, we examined the full IGH and kappa and lambd...
Hairy cell leukemia cells from eight different patients exhibited a characteristic cell surface glycoprotein pattern when labeled by the neuraminidase-galactose oxidase-NaB3H4 procedure. The diffuse high-molecular-weight glycoprotein band (Mr 230,000 to 300,000) was not seen in other leukemic cell types and may represent a specific hairy cell leukemia antigen. Hairy cell leukemia cells can be m...
Hairy cell leukemia has been shown to be strongly associated with the BRAF V600E mutation. We screened 59 unenriched archived bone marrow aspirate and peripheral blood samples from 51 patients with hairy cell leukemia using high resolution melting analysis and confirmatory Sanger sequencing. The BRAF V600E mutation was detected in 38 samples (from 36 patients). The BRAF V600E mutation was detec...
BACKGROUND Distinction between mature B-cell neoplasms can be difficult due to overlapping of immunologic features and clinical manifestations. This study investigated whether quantifying mean fluorescence intensity of four monoclonal antibodies in a flow cytometry panel is useful for the differential diagnosis and characterization of these disorders. METHODS The expressions of CD52, CD200, C...
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