The localization of gold in the synovial membrane of rheumatoid arthritis patients treated with sodium aurothiomalate was examined and quantitative analysis of epon-embedded sections was carried out with a wavelength dispersive x-ray microanalyser. Gold was only detected in the lysosomes of synovial lining type A cells and subsynovial mononuclear cells in the form of filamentous deposits and hi...

E.S. Rogers1, R. Sasidharan2, G.M. Sequeira3, M.R. Wood4, S.P. Bird5, B. Arroll1, J. Stewart1, J.W.L. Keogh6, R.D. Macleod7 Faculty of Medical and Health Sciences, The University of Auckland, Auckland, NEW ZEALAND Medical Oncology, Auckland City Hospital, Auckland, NEW ZEALAND School of Sport, Manukau Institute of Technology, Auckland, NEW ZEALAND Sport and Recreation, Auckland University of Te...

We report single molecule fluorescence studies on nanoporous gold films. We observed dramatically enhanced intensities in individual immobilized fluorophores and reduced effective observation volumes in the nanopores. The enhanced localized plasmon field existing in the "nanovoid" regions can be visualized from the overlaid mapping image derived from surface reflectance and fluorescence emission.

Since ancient times, noble gold has continuously contributed to several aspects of life from medicine to electronics. It perpetually reveals its new features. We report the finding of a unique form of gold, reticular nanostructured gold (RNG), as an aqueous black colloid, for which we present a one-step synthesis. The reticules consist of gold crystals that interconnect to form compact strands....

A patient with seropositive, nodular rheumatoid arthritis (RA) developed contact allergy to gold jewellery following a severe skin rash which occurred after 13 weeks of treatment with sodium aurothiomalate. Patch testing confirmed that the contact allergy was due to gold. This is the first proved case of contact allergy to gold or any other compound initiated by systemic administration of the a...

Gold thioglucose and gold sodium thiomalate were shown to be potent activators of latent human leukocyte collagenase. No activation by auranofin was noted. The activation may proceed through the action of gold on the essential sulfhydryl groups of latent enzyme and, thereby, mimick the action of the known organomercurial activators.

INTRODUCTION Pathology service in Ghana is still in its infancy due to inadequate personnel (Pathologists) and a poor perception of the role of the pathologist in health care delivery. The state of affairs in Ghana may be partly blamed on an accident of history, the anomaly resulting from which has been allowed to become the norm. In the days of the colonial administration of the Gold Coast, as...