A large number of pharmaceutically active compounds have a high affinity to acidic phospholipids; good examples are the cationic compounds lidocaine, propranolol, and gentamycin. These drugs influenced the lipid dynamics of liposomes composed of phosphatidylcholine and the acidic phosphatidylglycerol, as judged by the excimer/monomer emission intensity ratio for a pyrene-labeled phospholipid an...

the current treatment of choice for cutaneous leishmaniasis is either parenteral or intralesional antimonial compounds. each of these treatments has its own downfalls which include toxic side effects with the parentral injection and pain at the site of injection with the intralesional injection. in recent years, there has been more focus on paromomycin as an alternative drug; however, current d...

Background: Sea cucumbers have number of one a pharmacological effects counting anticancer, anticoagulant, anti-inflammatory, antioxidant, and wound healing. Biological properties therapeutic benefits can be connected to the presence wide cluster bioactive compounds particularly triterpene glycosides (saponins). Aims: The present study aimed explore hepatoprotective nephroprotective activity cu...

microRNAs (miRNAs) are promising biomarkers for different pathological models because of their stable and detectable characters in biofluids. Here, we collected urine samples from 5 beagle dogs on the 3th, 6th, 12th day an acute kidney injury (AKI) caused by gentamycin. miRNA levels were measured with high-throughput sequencing results then differentially investigated. Gene Ontology (GO) KEGG p...

Twelve, male albino mice, aged 6-8 weeks, were injected intraperitoneally, aqueous solution of gentamicin (80 mg / kg / day) for fifteen days and the effects observed on the kidney structure and function. Group A served as control while Group B was given gentamicin. At the end of the experiment, blood was drawn from each animal by cardiac puncture for renal function tests and kidneys were fixed...

clinical observations with gross and microscopic changes of acute chemical inflammation of fetlock joint by injecting turpentine oil and gentamycin in 4 donkeys 2 to 4 years of age and 150 to 200kg/bw were recorded. the animals coordination, pain at the site of injection, local heat joint circumferences and weight bearing after inducing arthritis in fetlock forelimb and hind limb were noted dow...