نتایج جستجو برای: gcb pwm

تعداد نتایج: 4927  

Journal: :Blood 2012
Mamta Gupta Matthew J Maurer Linda E Wellik Mark E Law Jing Jing Han Nazan Ozsan Ivana N Micallef Ahmet Dogan Thomas E Witzig

STAT3 regulates cell growth by up-regulating downstream targets, such as Myc. The frequency of phosphorylated STAT3 (pSTAT3) and Myc expression and their prognostic relevance is unknown within diffuse large B-cell lymphoma (DLBCL) germinal center B-cell (GCB) and non-GCB subtypes. pSTAT3 and Myc were studied by immunohistochemistry (IHC) on tumors from 40 DLBCL patients uniformly treated on a c...

Journal: :Saudi medical journal 2010
Abeer A Saad Nahla M Awed Zeinab M Abdel-Hafeez Gihan M Kamal Hala M Elsallaly Amal I Alloub

OBJECTIVE To study the expression of germinal center B-cell (GCB)/activated B-cell like-related proteins to get optimal stratification of diffuse large B-cell lymphoma (DLBCL) patients, and correlate this with the established clinical and laboratory parameters. METHODS This study was conducted retrospectively on 30 archival paraffin tissue blocks of DLBCL. All patients were diagnosed between ...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2011
Javeed Iqbal Paul N Meyer Lynette M Smith Nathalie A Johnson Julie M Vose Timothy C Greiner Joseph M Connors Louis M Staudt Lisa Rimsza Elaine Jaffe Andreas Rosenwald German Ott Jan Delabie Elias Campo Rita M Braziel James R Cook Raymond R Tubbs Randy D Gascoyne James O Armitage Dennis D Weisenburger Wing C Chan

PURPOSE We have previously shown the prognostic significance of BCL2 expression in the activated B-cell-like diffuse large B-cell lymphoma (ABC-DLBCL) patients treated with cyclophosphamide-Adriamycin-vincristine-prednisone (CHOP) or CHOP-like therapy. However, after the inclusion of rituximab (R) in the CHOP regimen, several conflicting observations about the prognostic value of BCL2 expressio...

2015
Jiao Ma Wei Xing Greg Coffey Karen Dresser Kellie Lu Ailin Guo Gordana Raca Anjali Pandey Pamela Conley Hongbo Yu Y. Lynn Wang

B-cell receptor (BCR) and JAK/STAT pathways play critical roles in diffuse large B-cell lymphoma (DLBCL). Herein, we investigated the anti-lymphoma activity of cerdulatinib, a novel compound that dually targets SYK and JAK/STAT pathways. On a tissue microarray of 62 primary DLBCL tumors, 58% expressed either phosphorylated SYK or STAT3 or both. SYK and STAT3 are also phosphorylated in a panel o...

Journal: :Scientific reports 2016
Ting-Xun Lu Yi Miao Jia-Zhu Wu Qi-Xing Gong Jin-Hua Liang Zhen Wang Li Wang Lei Fan Dong Hua Yao-Yu Chen Wei Xu Zhi-Hong Zhang Jian-Yong Li

Using an immunohistochemistry (IHC) based method, diffuse large B-cell lymphoma (DLBCL) can be classified into germinal center B-cell (GCB) and non-GCB subtypes. However, the prognostic value of Hans algorithm was contradictory in the literature. Using IHC and fluorescence in situ hybridization, we analyzed the antibodies applied in Hans algorithm and other genetic factors in 601 DLBCL patients...

Journal: :Blood 2010
Rita Shaknovich Huimin Geng Nathalie A Johnson Lucas Tsikitas Leandro Cerchietti John M Greally Randy D Gascoyne Olivier Elemento Ari Melnick

Expression profiling has shown 2 main and clinically distinct subtypes of diffuse large B-cell lymphomas (DLBCLs): germinal-center B cell-like (GCB) and activated B cell-like (ABC) DLBCLs. Further work has shown that these subtypes are partially characterized by distinct genetic alterations and different survival. Here, we show with the use of an assay that measures DNA methylation levels of 50...

Journal: :Blood 2006
Yun-Wen Chen Xiao-Tong Hu Anthony C Liang Wing-Yan Au Chi-Chiu So Michelle L Wong Lijun Shen Qian Tao Kent-Man Chu Yok-Lam Kwong Raymond H Liang Gopesh Srivastava

To investigate the role of BCL6 in the pathogenesis of gastric lymphoma, we analyzed the BCL6 promoter region for BCL6 translocations, somatic hypermutations, and deregulating mutations in 43 gastric lymphomas, including 4 extranodal marginal-zone B-cell lymphomas of mucosa-associated lymphoid tissues (MALT lymphomas), 33 diffuse large B-cell lymphomas (DLBCLs), and 6 composite DLBCLs with resi...

Journal: :Journal of clinical and experimental hematopathology : JCEH 2012
Toshiyuki Habara Yasuharu Sato Katsuyoshi Takata Noriko Iwaki Hirokazu Okumura Hiroshi Sonobe Takehiro Tanaka Yorihisa Orita Lamia Abd Al-Kader Naoko Asano Daisuke Ennishi Tadashi Yoshino

Diffuse large B-cell lymphoma (DLBCL) is the most common form of non-Hodgkin's lymphoma. Although many investigations have been performed on the prognostic factors of DLBCL, no reports have focused on localized nodal DLBCL. We examined the prognostic significance of 39 Japanese patients with localized nodal DLBCL with special reference to the germinal center B-cell-like (GCB) versus non-germina...

2010
Rita Shaknovich Huimin Geng Nathalie A. Johnson Lucas Tsikitas Leandro Cerchietti John M. Greally Randy D. Gascoyne Olivier Elemento Ari Melnick

Expression profiling has shown 2 main and clinically distinct subtypes of diffuse large B-cell lymphomas (DLBCLs): germinal-center B cell–like (GCB) and activated B cell–like (ABC) DLBCLs. Further work has shown that these subtypes are partially characterized by distinct genetic alterations and different survival. Here, we show with the use of an assay that measures DNA methylation levels of 50...

Journal: :British Journal of General Practice 2009

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