Processing of the amyloid precursor protein (APP) by beta- and gamma-secretases leads to the generation of amyloid-beta (Abeta) peptides with varying lengths. Particularly Abeta42 contributes to cytotoxicity and amyloid accumulation in Alzheimer's disease (AD). However, the precise molecular mechanism of Abeta42 generation has remained unclear. Here, we show that an amino-acid motif GxxxG withi...

For a dynamic limit order market, we present a Markov perfect equilibrium with Edgeworth cycles. In equilibrium, when sellers enter the market consecutively, the best quote decreases tick by tick, then jumps more than one tick, creating a hole in the book. The next quote rebounds to the less aggressive level, and the same cycle starts over again. Holes can relate to the high kurtosis of transac...

This paper examines the relationship between the board structure of UK firms and the accuracy of individual analysts’ earnings forecasts with respect to information asymmetry and agency theory. We hypothesize that managers of firms complying with the recommendations of The Code of Best Practice may have “less to hide” and, subsequently, provide more information to outsiders (including analysts)...

This paper uses a simple model of mean-variance capital markets equilibrium with proportional transactions costs to analyze the competition of stock markets for investors. We assume that equity trading is costly and endogenize transactions costs as variables strategically influenced by stock exchanges. Among other things, the model predicts that increasing financial market correlation leads to ...

This paper presents the results of a Spitzer IRAC 3−8 μm photometric search for warm dust orbiting 17 nearby, metal-rich white dwarfs, 15 of which apparently have hydrogen dominated atmospheres (type DAZ). G166-58, G29-38, and GD 362 manifest excess emission in their IRAC fluxes and the latter two are known to harbor dust grains warm enough to radiate detectable emission at near-infrared wavele...