Rapid and flexible interpretation of conflicting sensory inputs in the context of current goals is a critical component of cognitive control that is orchestrated by frontal cortex. The relative roles of distinct subregions within frontal cortex are poorly understood. To examine the dynamics underlying cognitive control across frontal regions, we took advantage of the spatiotemporal resolution o...

Abstract Primates are unique among mammals in possessing a region of dorsolateral prefrontal cortex with a well-developed internal granular layer. This region is commonly implicated in higher cognitive functions. Despite the histological distinctiveness of primate dorsolateral prefrontal cortex, the work of Rose, Woolsey, and Akert produced a broad consensus among neuroscientists that homologue...

Background/Aim.Since 2014 and the publication of results first study on accumulation gadolinium contrast, we have witnessed a growing body evidence deposition retention in brain after use gadolinium-based contrast agents (GBCAs). However, there is still no strong clinical adverse effects GBCAs brain. The aim was to determine existence deposits patients with realpsing-remiting (RR) multiple scle...

BACKGROUND Postmortem studies have documented abnormalities in the medial orbital frontal cortex in depressed patients. In this study we evaluated whether atrophy of this region can be identified in older depressed patients using magnetic resonance imaging. METHODS Twenty elderly patients meeting DSM-IV criteria for major depression and 20 matched control subjects were studied. The orbital fr...

The frontal cortex can be defined as the neocortex anterior to the motor somatosensory–cortex border. This is a large region in primates, containing areas involved directly or indirectly in the control of almost every behavior. It has long been thought that the frontal cortex played an important role in primate evolution. Modern evidence supports this view. Indeed, given the diversity of functi...

Summary Our judgments of our environment are often shaped by heuristics and prior experience. New research shows that the resulting biases encoded, combined with new sensory input, groups neurons in frontal cortex during decisions under uncertainty.