Pharmaceutical medications must be stable to preserve their efficacy and safety over the period of shelf lives. Studies on force degradation are crucial for identifying probable pathways extreme stresses that may lead breakdown pharmaceutical product. This report offers a thorough analysis tests performed Clomifene citrate tablets. Evaluation effects several stress factors, including temperatur...

Chemically Losartan is {2-N-butyl-4-chloro-5-hydroxymethyl-1-[(2′(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazole}. it is a typical angiotensin II (Ang II) type I receptor (AT1R) blocker that has been used for regulation of blood pressure and fluid homeostasis. Forced degradation studies are used to identify reactions which may occur to degrade a processed product. Usually conducted before fina...

Amlodipine is a long-acting calcium channel blocker used in the treatment of hypertension and angina pectoris. S-(−)-amlodipine besylate is a safer and longer-acting alternative to the existing racemate [1]. Although several products based on the active enantiomer have reached the market, information on its chemical, physical and thermal stability during storage is lacking [2, 3]. The objective...

Forced degradation study on doxorubicin (DOX) was carried out under hydrolytic condition in acidic, alkaline and neutral media at varied temperatures, as well as under peroxide, thermal and photolytic conditions in accordance with International Conference on Harmonization (ICH) guidelines Q1(R2). It was found extremely unstable to alkaline hydrolysis even at room temperature, unstable to acid h...

Over-production of hydrogen peroxide (H2O2) will lead to human osteoblast dysfunction and apoptosis, causing progression of osteoporosis and osteonecrosis. NF-E2-related factor 2 (Nrf2) is a well-characterized anti-oxidant signaling. Cullin 3 (Cul3) ubiquitin E3 ligase dictates Nrf2 degradation. We demonstrate that microRNA-455 ("miR-455") is a putative Cul3-targeting microRNA. Forced-expressio...

Chlorthalidone was subjected to various forced degradation conditions. Substantial degradation of chlorthalidone was obtained in acid, alkali, and oxidative conditions. Further full factorial experimental design was applied for acid and alkali forced degradation conditions, in which strength of acid/alkali, temperature, and time of heating were considered as independent variables (factors) and ...