s: Assessment of Publication Bias In addition to the fully-published reports of head-to-head trials cited above, we found three studies that were published in abstract format only, at the time of writing (see Table 7). Two of these may be interim analyses of included studies, and do not present enough data to compare to published studies. 58 One study appears to be independent of the included s...

PURPOSE Our objective was to estimate the economic outcomes of using mirabegron versus antimuscarinics in the treatment of patients with overactive bladder (OAB) from a societal perspective in the UK. MATERIALS AND METHODS A Markov model was developed using Microsoft Excel®. The time horizon and cycle length are 12 and 1 months, respectively; and the hypothetical cohort size 100 patients. Ant...

OBJECTIVE To review the efficacy of drug therapy for urinary urge incontinence by examining the published literature. METHODS OF STUDY SELECTION In October 1999, we searched the medical databases MEDLINE, EMBASE, and Cochrane Controlled Trials Register to identify prospective randomized, double-blind, placebo-controlled clinical trials in the English literature evaluating drug therapy (except...

To explore the potential role of some bacterial metabolites of chloramphenicol (CAP) in CAP-induced hematotoxicity, we examined their cytotoxic effects on bone marrow cells in vitro using a number of cytotoxicity parameters. Among the metabolites tested, dehydro-CAP (DHCAP) and p-nitrophenyl-2-amino-3 hydroxypropanone-HCI (NPAP) were more toxic than CAP. DHCAP was at least as toxic as nitroso-C...

A prospective study was done in pediatric out-patient department of a tertiary care hospital to evaluate the role of urodynamics in the management of primary enuresis in the 5-14-year-old children and to compare the effectiveness of multidimensional behavioral therapy with pharmacological therapy. Hundred and nineteen children between 5-14 years with primary enuresis were evaluated clinically a...

Medical workflow during doctor-patient consultations is rapidly changing due to the introduction of technologies such as electronic medical records (EMR). This transition has a significant impact on the quality of doctor-patient interactions, resulting in increased cognitive load on doctors, and lowered patient satisfaction. The UCSD DCOG-HCI lab at UCSD is developing a novel interactive medica...

Acute scrotum, an unusual manifestation of non-gonococcal urethritis (NGU), epididymitis and orchitis, in a middle aged man is described with cardinal clinical features characterizing it as a syndrome. Investigations were corroborative to conform to non sexually transmitted disease. E. Coli, sensitive to levofloxacin, was recovered on culture, which showed an affirmative response to levofloxaci...

With an estimated 16.5% of Americans experiencing symptoms from overactive bladder (OAB) and urinary incontinence (UI), this condition deserves continued research focus.1 In this issue of JMCP, D’Souza et al. present a retrospective claims database analysis of adherence, persistence, and switching behaviors, comparing cohorts of patients using different medications to treat OAB.2 D’Souza et al....

BACKGROUND Pharmacotherapy constitutes an important adjunct to behavioral therapy for the treatment of overactive bladder (OAB). Tolterodine and oxybutynin are commonly prescribed drugs for OAB treatment that exert their beneficial effect by suppressing bladder muscle contractions. However, high discontinuation rates have been observed for these drugs in clinical trials, as well as in real-worl...