نتایج جستجو برای: endocrine related cancer

تعداد نتایج: 2032507  

Journal: :Journal of molecular endocrinology 2012
Abby F Fleisch Robert O Wright Andrea A Baccarelli

Endocrine disrupting chemicals that are structurally similar to steroid or amine hormones have the potential to mimic endocrine endpoints at the receptor level. However, more recently, epigenetic-induced alteration in gene expression has emerged as an alternative way in which environmental compounds may exert endocrine effects. We review concepts related to environmental epigenetics and relevan...

2017
Vincenzo Quagliariello Sabrina Rossetti Carla Cavaliere Rossella Di Palo Elvira Lamantia Luigi Castaldo Flavia Nocerino Gianluca Ametrano Francesca Cappuccio Gabriella Malzone Micaela Montanari Daniela Vanacore Francesco Jacopo Romano Raffaele Piscitelli Gelsomina Iovane Maria Filomena Pepe Massimiliano Berretta Carmine D’Aniello Sisto Perdonà Paolo Muto Gerardo Botti Gennaro Ciliberto Bianca Maria Veneziani Francesco De Falco Piera Maiolino Michele Caraglia Maurizio Montella Rosario Vincenzo Iaffaioli Gaetano Facchini

This review summarizes the main pathophysiological basis of the relationship between metabolic syndrome, endocrine disruptor exposure and prostate cancer that is the most common cancer among men in industrialized countries. Metabolic syndrome is a cluster of metabolic and hormonal factors having a central role in the initiation and recurrence of many western chronic diseases including hormonal-...

Journal: :Clinical endocrinology 2016
Sabashini K Ramchand Elgene Lim Mathis Grossmann

Adjuvant endocrine therapy provides oncological benefits in women with early oestrogen-receptor-positive breast cancer, but has adverse effects consequent to induced oestradiol deficiency. Bone loss is accelerated, predisposing to increased fracture risk. Metabolic effects include changes in lipid metabolism and body composition although effects on cardiovascular risk are still unclear. Women c...

Journal: :Arhiv za higijenu rada i toksikologiju 2016
Vesna Zadnik Mateja Krajc

The incidence of hormone-related cancers tends to be higher in the developed world than in other countries. In Slovenia, six hormone-related cancers (breast, ovarian, endometrial, prostate, testicular, and thyroid) account for a quarter of all cancers. Their incidence goes up each year, breast and prostate cancer in particular. The age at diagnosis is not decreasing for any of the analysed canc...

Journal: :Toxicology 2012
Anja Olsen Jane Christensen Malene Outzen Pelle Thonning Olesen Henrik Frandsen Kim Overvad Jytte Halkjær

Acrylamide is a probable human carcinogen, with industrial contact, tobacco smoking and foods processed at high temperatures as the main routes of exposure. In animal studies oral intake of acrylamide has been related to cancer development, with indications that the increased cancer occurrence especially regards endocrine related tumors. In human epidemiological studies, dietary exposure to acr...

Thyroid cancer is the most common endocrine malignant tumor, and its incidence is on the rise. A survey conducted by the Iranian Cancer Institute showed that thyroid cancer constitutes 1.8% of all cancers and 76.1% of endocrine cancers. A lot of studies are being conducted in order to prevent, alleviate pain, and treat cancer using medicinal herbs. Medicinal herbs are important sources of, and ...

2013
Keren Merenbakh-Lamin Noa Ben-Baruch Adva Yeheskel Addie Dvir Lior Soussan-Gutman Rinath Jeselsohn Roman Yelensky Myles Brown Vincent A. Miller David Sarid Shulamith Rizel Baruch Klein Tami Rubinek Ido Wolf

Resistance to endocrine therapy occurs in virtually all patients with estrogen receptor a (ERa)-positive metastatic breast cancer, and is attributed to various mechanisms including loss of ERa expression, altered activity of coregulators, and cross-talk between the ERa and growth factor signaling pathways. To our knowledge, acquiredmutations of the ERa have not been described asmediating endocr...

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