نتایج جستجو برای: elston
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سابقه و هدف: یکی از اهداف علم اپیدمیولوژی ژنتیک یافتن دقیق مکان ژنتیکی در ارتباط با یک فنوتیپ خاص است. گام موثر در این مسیر پر فراز و نشیب، تحلیل پیوستگی ژنتیکی این فنوتیپها و نزدیک شدن به مکان ژنی آنهاست. روش آماری رایج جهت تحلیل پیوستگی ژنتیکی فنوتیپهای کمی روشهای رگرسیونی haseman-elston (یا he) است که در حال حاضر هفت نوع از این روشها بهطور رایج مورد کاربرد است. تغییرات hdl-c یکی از فنوتیپهای...
Complete List of Authors: Tunceli, Kaan; Henry Ford Health System, Center for Health Services Research Bradley, Cathy; Virginia Commonwealth University, Department of Health Administration Elston Lafata, Jennifer; Henry Ford Health System, Center for Health Services Research Pladevall, Manel; Henry Ford Health System, Center for Health Services Research Goodman, Allen; Wayne State University, D...
We consider blind, deterministic, finite automata equipped with a register which stores an element of a given monoid, and which is modified by right multiplication by monoid elements. We show that, for monoids M drawn from a large class including groups, such an automaton accepts the word problem of a group H if and only if H has a finite index subgroup which embeds in M . In the case that M is...
A Taylor series approximation to multivariate integrals taken with respect to a multivariate probability distribution is proposed and applied to the computation of multivariate normal probabilities and conditional expectations. The approximation does not require that the multivariate distribution have a structured covariance matrix and, in its simplest form, can be written as the product of uni...
Dirk M. Elston, MD, James S. Taylor, MD, Brett Coldiron, MD, Antoinette F. Hood, MD, Sandra I. Read, MD, Jack S. Resneck, Jr, MD, Robert S. Kirsner, MD, PhD, John C. Maize, Sr, MD, Sabra Sullivan, MD, PhD, John Laskas, Jr, MD, and C. William Hanke, MD Danville and Glen Mills, Pennsylvania; Cleveland and Cincinnati, Ohio; Detroit, Michigan; Norfolk, Virginia; Washington, DC; San Francisco, Calif...
The power of linkage analysis of a quantitative disease endophenotype was compared for the following family selection designs: 1) Random samples: randomly chosen nuclear families, 2) "coronary artery calcification (CAC)" samples: selection of each nuclear family through a proband with abnormally high levels of the simulated quantitative endophenotype, CAC, and (3) "MI" samples: selection of eac...
Estimating SNP-heritability from summary statistics using LD Score regression provides a convenient alternative to standard variance component models, because LD Score regression is computationally very fast and does not require individual genotype data. However, the mathematical relationship between variance component methods and LD Score regression is not clear; in particular, it is not known...
In this paper, we close the study on the self-motional behavior of nonarchitecturally singular parallel manipulators of Stewart Gough (SG) type, where the planar platform and the planar base are related by a projectivity κ , by showing that planar projective SG platforms with elliptic self-motions do not exist. The proof of this result demonstrates the power of geometric and computational inter...
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