In an effort to discover an effective and selective antitumour agent, synthesis and anti-cancer potential of 4-(pyridin-4-yl)-6-(thiophen-2-yl)pyrimidin-2(1H)-one (SK-25), which has been reported earlier by us with significant cytotoxicity towards MiaPaCa-2 malignant cells, with an IC50 value of 1.95 μM and was found to instigate apoptosis. In the present study, the antitumour efficacy of SK-25...

The E2 hypotetraploid Ehrlich ascites tumor reached its peak size at 1 X IO9 cells on the 14th day after i.p. inoculation of 0.30 X 10* cells. During this period the % nonviable Ehrlich ascites tumor cells did not change. Autoradiographic studies during the first 14 days of Ehrlich ascites tumor growth dem onstrated no decrease in the % tumor cells incorporating tritiated uridine, proline, phen...

1-Methyl-3-nitro-l-nitrosoguanidine (nitrosoguanidine) was tested for activity against leukemia L1~10 (ascites and solid), Sarcoma 180 (ascites and solid), Ehrlich carcinoma (ascites and solid), 6CSHED ascites lymphosarcoma, and Mecca ascites lymphosarcoma in mice. Nitrosoguanidine was active against all the ascites tumors cxcept Mecca; it was inactive against the three solid tumors. When used ...

The antitumor effects of 6-mercaptopurine (6MP) and 6-(methylmercapto)purine ribonucleoside (MeoMPR) are dis tinctly potentiated when these agents are used together in the treatment of certain mouse tumors, including the Ehrlich ascites carcinoma. This paper is concerned with the biochem ical mechanism of this potentiation. Prior treatment of Ehrlich ascites carcinoma cells with MeoMPR enhanced...

Using a recently developed technique of direct tracer injection into selective adipose tissue sites (Baker et al., Mech. Ageing Dev., 27: 295-313, 1984), we have studied the esterification of free fatty acids (FFA) to triglyceride fatty acids in the epididymal fat pads of normal and Ehrlich ascites carcinoma-bearing mice. We have tested the hypothesis that, during Ehrlich ascites carcinoma grow...

The antitumor effects of 6-mercaptopurine (6MP) and 6-(methylmercapto)purine ribonucleoside (MeoMPR) are dis tinctly potentiated when these agents are used together in the treatment of certain mouse tumors, including the Ehrlich ascites carcinoma. This paper is concerned with the biochem ical mechanism of this potentiation. Prior treatment of Ehrlich ascites carcinoma cells with MeoMPR enhanced...

This Article contains typographical errors. In the Results section under subheading 'In vivo anticancer activity against Ehrlich ascites Carcinoma (EAC)' " The experimental results showed that 3-AWA reduced Ehrlich ascites carcinoma by 71.75% at 10 mg/kg intra-peritoneal dose in comparison to the tumor growth inhibition of 87.4% in 5-FU (22 mg/kg i.p.) treated group. " should read: " The experi...

Melothria heterophylla (Lour.) Cogn., (family-Cucurbitaceae) popularly known as kundari, has been shown to exhibit antioxidant effects. The main objective was to isolate active constituents of the plant extract. In this study, the ability of M. heterophylla to induce apoptosis was studied in Ehrlich ascites carcinoma cells. Treatment of the Ehrlich ascites carcinoma cells with a variety of conc...