objectives: graft versus host disease (gvhd) is a life threatening reaction in the stem cell transplantation process. nowadays cyclosporine is the most commonly utilized agent for gvhd prophylaxis and it has a major role in successful transplantation. cyclosporine has been applied for many years in this field but it could be stated that currently no general consensus is available for its optima...

Chambers and Quiggin (2000) advocate the use of state-contingent production technologies to represent risky production and establish important theoretical results concerning producer behaviour under uncertainty. Unfortunately, perceived problems in the estimation of state-contingent models have limited the usefulness of the approach in policy formulation. We show that fixed and random effects s...

SUMMARY A marginal model for the analysis of binomial data involving one or two random factors is presented. Two variance-covariance models are derived based on the multiplicative error formulation. The parameters of mean and variance components are estimated using the quasi-likelihood and method of moments, respectively. An application of the model is illustrated by an analysis of multivariate...

Phenytoin is a commonly used antiepileptic medication in the pediatric age group, but it has a narrow therapeutic range. Various adverse effects have been reported commonly. We report a relatively rare case of encephalopathy in a child from overdose of injectable phenytoin due to ignorance of the previous treatment. Scrutiny of medical records and history is of utmost importance while administe...

The introduction of topical steroids (TS) of varying potency have rendered the therapy of inflammatory cutaneous disorders more effective and less time-consuming. However the usefulness of these has become a double edged sword with constantly rising instances of abuse and misuse leading to serious local, systemic and psychological side effects. These side effects occur more with TS of higher po...

voriconazole is an antifungal triazole, approved for management of invasive fungal diseases in patients. it is absorbed during two hours and its serum levels will be above 90%, based on the underlying factors, when the drug is administered orally. voriconazole shows a propotional increase in an area under the plasma concentration-time curve (auc), with increasing dose. plasma protein binding of...