Dietary restriction (DR) extends lifespan in many species which is a well-known phenomenon. Long non-coding RNAs (lncRNAs) play an important role in regulation of cell senescence and important age-related signaling pathways. Here, we profiled the lncRNA and mRNA transcriptome of fruit flies at 7 day and 42 day during DR and fully-fed conditions, respectively. In general, 102 differentially expr...

BACKGROUND AND OBJECTIVE Persistent hepatic progenitor cells (HPC) activation resulting in ductular reaction (DR) is responsible for pathologic liver repair in cholangiopathies. Also, HPC/DR expansion correlates with fibrosis in several chronic liver diseases, including steatohepatitis. Increasing evidence indicates Notch signaling as a key regulator of HPC/DR response in biliary and more in ge...

PURPOSE Trans-signaling of interleukin (IL)-6 through its soluble receptor (sIL-6R) is critically involved in the promotion of chronic inflammatory diseases. The aim of the present study was to estimate IL-6, sIL-6R, and soluble gp130 (sgp130, a natural antagonist of IL-6 trans-signaling) concentrations in the serum and aqueous humor (AqH) of patients with diabetic retinopathy (DR). METHODS P...

Maternal effects of environmental conditions produce intergenerational phenotypic plasticity. Adaptive value of these effects depends on appropriate anticipation of environmental conditions in the next generation, and mismatch between conditions may contribute to disease. However, regulation of intergenerational plasticity is poorly understood. Dietary restriction (DR) delays aging but maternal...

Diabetic retinopathy (DR) is a serious microvascular complication of diabetes, which causes visual disability and blindness. Several studies have used gene expression profiling of DR to identify the key genes involved in this process; however, few studies have focused on the associated pathways and transcription factors (TFs), or on the co-expression patterns at the multiple pathways level. In ...

The hedgehog (Hh) pathway, initially discovered in Drosophila by two Nobel laureates, Dr. Eric Wieschaus and Dr. Christiane Nusslein-Volhard, is a major regulator for cell differentiation, tissue polarity and cell proliferation. Studies from many laboratories, including ours, reveal activation of this pathway in most basal cell carcinomas and in approximately 30% of extracutaneous human cancers...

Protein-protein interactions between G protein-coupled receptors (GPCRs) can augment their functionality and increase the repertoire of signaling pathways they regulate. New therapeutics designed to modulate such may allow for targeting a specific GPCR activity, thus reducing potential side effects. Dopamine receptor (DR) heteromers are promising candidates targeted therapy neurological conditi...

10:00-12:15 Session 1 Chair: Dr. Yuki Eshita 10:10-10:40 Dr. Yuki Eshita: Susceptibility of Japanese Aedes (Stegomyia) mosquitoes to arboviruses 10:45-11:15 Dr. Kenji Abe: Rubella outbreak among children in Vietnam: Molecular characterization of virus and its pathogenesis in human fetuses 11:20-11:50 Dr. Hideo Negishi: Regulation of pattern recognition receptor signaling -Control of gene induct...

At the quarterly clinicopathological conference held at the Royal College of Physicians on 26 July 1979 Dr C C Booth (1) took the chair. He opened the conference by saying that it would take an unusual reverse form in which a pathologist, Dr I Doniach, would be invited to comment on the pathological findings and reconstruct the clinical history and that the true clinical history would be reveal...