Integrated Discrete Multiple Organ Co-culture (IDMOC) is emerging as an in-vitro alternative to in-vivo animal models for pharmacology studies. IDMOC allows dose-response relationships to be investigated at the tissue and organoid levels, yet, these relationships often exhibit responses that are far more complex than the binary responses often measured in whole animals. To accommodate departure...

The concept of dose-response linearity has been in practice for risk assessment of chemical carcinogens and ionising radiation for the past 30 years. But in recent years the evidence from cancer mortality studies and new radiobiological phenomena such as genomic instability, the bystander effect and adaptive response have challenged this accepted hypothesis questioning whether low dose linearit...

BACKGROUND AND OBJECTIVES FE 999049 is a novel recombinant follicle-stimulating hormone (rFSH) preparation expressed by a human cell line (PER.C6(®)), in contrast to existing rFSH preparations expressed by Chinese hamster ovary (CHO) cell lines. Since the individual dose of rFSH may be altered depending on the response in women undergoing assisted reproductive technologies, knowledge on the dos...

Determining the pharmacokinetics (PKs) of drug candidates is essential for understanding their biological fate. The ability to obtain human PK information early in the drug development process can help determine if future development is warranted. Microdosing was developed to assess human PKs, at ultra-low doses, early in the drug development process. Microdosing has also been used in animals t...

This article assesses the historical foundations of how linearity at low dose became accepted by the scientiWc/regulatory communities. While the threshold model was used in the 1920s/1930s in establishing radiation health standards, its foundations were challenged by the genetics community who argued that radiation induced mutations in reproductive cells followed a linear response, were cumulat...

Background: The HU linearity is an essential parameter in a quantitative imaging and the treatment planning systems of radiotherapy. Objective: This study aims to evaluate the linearity of Hounsfield unit (HU) in applying the adaptive iterative dose reduction (AIDR) on CT scanner and its comparison to the filtered back-projection (FBP).Material and Methods: In this experimental phan...

In the present study we report dosimetric properties of iodized salt aiming at using it as an accidental luminescent dosimeter. It was found that the very good sensitivity of its main dosimetric peak is strongly affected by thermal treatments. This is also the case for OSL emission. The sensitivity loss due to heating implies that caution should be exercised while applying single aliquot protoc...