Siderite (FeCO3) is an important reduced phase iron mineral and end product of bacteria anaerobic respiration. This study addresses its dissolution behavior in the presence of the oxidant chromate, which is a common environmental contaminant. Macroscopic dissolution experiments combined with microscopic observations by atomic force microscopy show that at pH < 4.5 the dissolution rate with chro...

This study describes various complications related to sample preparation (filtration) during development of a dissolution method intended to discriminate among different fenofibrate immediate-release formulations. Several dissolution apparatus and sample preparation techniques were tested. The flow-through cell apparatus (USP 4) was found unfit for dissolution testing of fenofibrate MeltDose fo...

Salisilamida termasuk golongan obat AINS (anti inflamasi non steroid)memiliki efek analgesik dan antipiretik mirip dengan asam asetil salisilat, namun di dalam tubuh tidak diubah menjadi salisilat. Dalam penggunaan secara oral,salisilamida menimbulkan radang pendarahan pada lambung. merupakan senyawaasam lemah (pKa 8,2) yang kelarutannya dipengaruhi oleh pH lingkungan. Pada pemberian oral, sali...

piroxicam (px), an anti-inflammatory drug, exhibits poor water solubility, dissolution and flow properties. thus, the aim of the present study was to improve the solubility and dissolution rate of px by freeze drying technique using dimethylformamide (dmf), chloroform and water as co-solvent system. the prepared crystals containing px were evaluated for dmf and chloroform solvent residual by ga...

the formulation of hydrophobic drugs for oral drug delivery is challenging due to poor solubility, poor dissolution and poor wetting of these drugs. consequently, the aim of this study was to improve the dissolution of a model poorly water soluble drug, ibuprofen. microparticles containing ibuprofen were produced by spray drying and spray chilling technology in the absence/presence of a hydroph...

Clarithromycin (CLA), a broad-spectrum macrolide, is a poorly soluble drug with dissolution rate limited absorption. The aim of this investigation was to prepare CLA nanoparticles from a ternary ground mixture in the presence of sodium lauryl sulfate (SLS) and polyvinyl pyrrolidone (PVP) as co-grinding water-soluble compounds, in order to improve the drug dissolution rate. Different weight rati...

Paracetamol is an important anti-inflammatory and analgesic drug widely used in biological disorders. One of major problems with this drugs is its low solubility thus dissolution rate in biological fluid, which results into poor bioavailability after oral administration. In this study polyvinyl pyrrolidone (PVP) is used to enhance bioavailability of paracetamol. Paracetamol and PVP are used in ...

The rate-limiting step to drug absorption is often dissolution from the dosage form, especially for poorly soluble compounds. Two possibilities for improving the dissolution of these drugs are to increase the available surface area and to improve their apparent solubilities under physiologically relevant conditions with surfactants as wetting agents. Albendazole (ABZ), one of the most effective...

The potential of terahertz pulsed imaging (TPI) to predict the dissolution performance in sustained-release tablets was investigated in this study. Batches of coated tablets with similar weight gain during the coating process at the lab and pilot scales were subjected to non-destructive imaging by TPI and subsequently analysed by dissolution testing. The results from the dissolution tests revea...

introduction the iran has vast areas of karst landforms due to the relatively high carbonaceous rocks deposited during different geologic eras. karst landforms are noteworthy for investigation from many aspects. the primary importance of these regions is the considerable amount of underground water stored in karst formations. these reserves are favorable, both in quality and quantity, as natura...