dickkopf

Journal: :Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2013

Rodrigo B de Oliveira Fabiana G Graciolli Luciene M dos Reis Ana L E Cancela Lilian Cuppari Maria E Canziani Aluizio B Carvalho Vanda Jorgetti Rosa M A Moysés

BACKGROUND Mineral bone disorder (MBD) is an early complication of chronic kidney disease (CKD), with complex interactions in the bone-kidney-energy axis. These events lead to impaired bone remodelling, which in turn is associated with cardiovascular disease. Recently, we reported on a positive effect of phosphate binder treatment on bone remodelling markers and a reduction in serum FGF-23 leve...

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Smooth muscle cells differentiated from reprogrammed embryonic lung fibroblasts through DKK3 signaling are potent for tissue engineering of vascular grafts.

Journal: :Circulation research 2013

Eirini Karamariti Andriana Margariti Bernhard Winkler Xiaocong Wang Xuechong Hong Dilair Baban Jiannis Ragoussis Yi Huang Jing-Dong J Han Mei Mei Wong Can M Sag Ajay M Shah Yanhua Hu Qingbo Xu

RATIONALE Smooth muscle cells (SMCs) are a key component of tissue-engineered vessels. However, the sources by which they can be isolated are limited. OBJECTIVE We hypothesized that a large number of SMCs could be obtained by direct reprogramming of fibroblasts, that is, direct differentiation of specific cell lineages before the cells reaching the pluripotent state. METHODS AND RESULTS We ...

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