An investigation of the metabolic behavior of dimethyland monomethylaminoethanol was undertaken as a further study of members of the general class of N-methyl compounds. l It was hoped, however, that in the study of these particular compounds some clue might be uncovered as to the mechanism by which choline is synthesized and degraded in the course of participating in transmethylation reactions...

M.I.T. Quart. Prog. Rept., 50, 11 (1963); (f) McLean, A. D., J. Chem. Phys., 32, 1959 (1960). 6 Clementi, E., C. Roothaan, and M. Yoshimine, Phys. Rev., 127, 1618 (1962). 7K = 1.75, a(2s)= -0.559 au; a(2p)= -0.312 au; a(H) -0.50 au. 8 For BH a(2s) = -0.909 au; a(2p) = -0.314 au; a(H) = -0.591 au. For BB a(2s) -0.920 au; a(2pr) = -0.189 au; a(2pir) = -0.179 au. 9 Newton, M. D., unpublished work....

Electrochemical dehalogenation of polyhalogenated compounds is an inefficient process as the working electrode passivated by deposition short-chain polymers that form during early stages electrolysis. Herein, we report use 1, 3, 3-hexaflouroisopropanol (HFIP) efficient reagent to control C–H formation over radical association. Debromination 1,6-dibromohexane was examined in presence Ni(II) sale...

It is now well-known that (2)H solid-state NMR techniques can bring a better understanding of the interaction of deuterium with metal atoms in organometallic mononuclear complexes, clusters or nanoparticles. In that context, we have recently obtained experimental quadrupolar coupling constants and asymmetry parameters characteristic of deuterium atoms involved in various bonding situations in r...

BACKGROUND We developed a method to determine the urinary concentrations of metabolites in the synthetic pathway for carnitine from N(6)-trimethyllysine and applied this method to determine their excretion in control individuals. In addition, we investigated whether newborns are capable of carnitine synthesis from deuterium-labeled N(6)-trimethyllysine. METHODS Urine samples were first deriva...

Chiral compounds arising from the replacement of hydrogen atoms by deuterium are very important in organic chemistry and biochemistry. Some of these chiral compounds have a non-measurable specific rotation, owing to very small differences between the isotopomeric groups, and exhibit cryptochirality. This particular class of compounds is difficult to synthesize and characterize. Herein, we prese...

N-Heterocyclic carbenes (NHCs) promote the transfer hydrogenation of various activated C=C, C=N, and N=N bonds with water as the proton source. The NHCs act as reducing reagents to be converted into their oxides. A detailed reaction mechanism is proposed on the basis of deuterium-labeling experiments.