Twelve dogs with hypoadrenocorticism were treated with subcutaneous desoxycorticosterone pivalate (DOCP). Eight of these dogs were recently diagnosed and had not yet been treated. Four dogs previously had been diagnosed and treated (three with intramuscular DOCP, one with oral fludrocortisone acetate). History, physical examination, serum electrolytes, and blood urea nitrogen (BUN) were evaluat...

Glycyrrhizin decreased the resistance of intact male mice to prolonged exposure to cold (8 hours at 5 degrees C.) and it decreased the ability of intact male rats to mobilize glucose when subjected to 48 hours of fasting. It is suggested that glycyrrhizin, like desoxycorticosterone, depresses the output of ACTH.

Triamcinolone produced cleft palates in mouse embryos at a dosage proportionate, by body weight, to common therapeutic dosage for humans. Thus, it showed much greater teratogenicity than other glucocorticoids tested on mice. Widely ranging doses of desoxycorticosterone did not produce cleft palates.

a series of 1,4-dihydropyridine calcium channel blockers bearing 1-(4-x -benzyl)-5-imidazolyl substituent at 4 position (5a-e) (x=h, f) were synthesized and tested for antihypertensive activity in desoxycorticosterone acetate (doca)-induced hypertension in rats. amlodipine was used as the standard dihydropyridine. all compounds tested showed lower antihypertensive activity than that of amlodipi...

Estrogens tend to lower the blood pressure of cockerels. Estrogen-treated cockerels and estro-gen-secreting hens are immune to the chronic pressor effects of desoxycorticosterone acetate (DCA) and cortisone. B OTH desoxycorticosterone acetate (DCA) and cortisone effect moderate hypertension in cockerels." 2 The present studies demonstrate that estrogen-treated cockerels and estrogen-secreting h...