BACKGROUND Sinonasal undifferentiated carcinoma (SNUC) is a rare, aggressive malignancy of unknown etiology with a poor overall prognosis. Its relative rarity has made it difficult to determine the impact of different treatment modalities on survival. METHODS Retrospective study of cases in the National Cancer Data Base (NCDB). NCDB cases that were diagnosed as having SNUC between January 1, ...

Severe late toxicity following chemoradiotherapy in esophageal cancer, especially cardiac toxicity, is sometimes difficult to treat and is associated with mortality. However there is little published information with regard to patients with delayed pericardial effusion following chemoradiotherapy and its management. We herein report the case of a 63-year-old man with advanced synchronous esopha...

Superficial esophageal squamous cell cancer (SESCC) is often managed with esophagectomy with or without chemoradiotherapy. Esophagectomy has a significant complication rate and is not an option for many patients. In the current issue, a retrospective single center study evaluated 66 patients with SESCC. With endoscopic resection followed by adjuvant chemoradiotherapy, the reported 1-, 3- and 5-...

Background and Aims: Chemotherapy is utilized as a part of combined-modality programs to achieve organ preservation and improve survival in patients with locally advanced head and neck cancer. Combinedmodality protocols can be used in three forms: a) neoadjuvant induction chemotherapy before definitive surgery or radiotherapy; b) concomitant chemoradiotherapy; and c) sequential therapy consisti...

The standard treatment for patients with clinical T1bN0M0 esophageal squamous cell carcinoma is radical esophagectomy. Definitive chemoradiotherapy regarded as a option, and recently, good outcomes of this have been reported. This study compared prognosis after definitive From January 2011 to December 2019, 68 consecutive who were diagnosed enrolled investigated retrospectively. Patients classi...

BACKGROUND The objective of this article was to review randomized clinical trials (RCTs) utilizing pre- and postoperative treatment modalities for esophageal squamous cell carcinoma (ESCC). MATERIALS AND METHODS A computerized (MEDLINE) and manual search was performed to identify articles published on this topic between 1984 and 2012. RESULTS We identified a total of 49 published RCTs, whic...

critical, because true progressors require a change in treatment, but pseudoprogressors should continue with adjuvant temozolomide. Currently, there are no definitive radiologic criteria to differentiate between true progression and pseudoprogression. The response criteria for brain tumours developed by the Response Assessment in Neuro-Oncology Working Group state that apparent radiologic progr...

BACKGROUND AND STUDY AIMS Endoscopic resection is one treatment option for residual or locally recurrent esophageal cancer after definitive chemoradiotherapy or radiotherapy alone. However, little is known about the clinical benefit of salvage endoscopic resection for these lesions. Therefore, the effectiveness and prognostic factors of salvage endoscopic resection were investigated. PATIENTS...

Cisplatin-based concurrent chemoradiation plays an undisputed key role as definitive treatment in unresectable patients with locally advanced squamous cell carcinoma head and neck or as an organ preservation strategy. Treatment with 100 mg/m2 3-weekly cisplatin is considered the standard of care but is often associated with several adverse events. The optimum drug schedule of administration rem...

BACKGROUND The appropriate management of the neck in patients with regionally advanced head and neck cancer remains controversial. The purpose of this study was to retrospectively analyze our institutional experience with up-front neck dissection followed by definitive chemoradiotherapy. METHODS Fifty-five patients with radiographic evidence of large or necrotic lymph nodes underwent up-front...