We have previously identified a crude extract of the plant Chamaecrista nictitans (Fabaceae) with antiviral activity against herpes simplex virus. The main objectives of this research were to identify the step of the replication cycle of herpes simplex inhibited by the extract, and to attempt to characterize the chemical characteristics of this extract. The crude extract from--Chamaecrista nict...

Hybridoma cell lines that secrete monoclonal antibodies which react with HeLa cell surface antigens were produced. The monoclonal antibodies prevented cytopathic effects caused by coxsackievirus B1 and significantly reduced the amounts of coxsackieviruses B1, B5, and B6 that absorb to HeLa cells. These antibodies did not protect the cells from poliovirus cytopathic effects, and they had no effe...

In November 1963 a cytopathic agent was isolated from a baby who died in the Royal Manchester Children's Hospital. This agent produced an unfamiliar effect in cell cultures, and further studies confirmed that this effect was unlike anything previously encountered by us. Since then five other agents, producing similar cytopathic effects in cell cultures, have been isolated in the Public Health L...