نتایج جستجو برای: cyp2d6

تعداد نتایج: 2395  

Hoda Lavasani, Mohammad-Reza Rouini, Yalda Hosseinzadeh Ardakani

The stereoselective pharmacokinetic of Tramadol (T) and its main metabolites concerning the influence of CYP2D6 phenotype and gender on the phase I metabolism of this compound was studied after administration of 100 mg single oral dose of racemic T to 24 male and female subjects. The pharmacokinetic parameters were estimated from plasma concentrations of the analytes enantiomers. The metabolic ...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 1999
S L Wang M D Lai J D Huang

The molecular basis of the reduced ability of a Chinese to metabolize debrisoquine was explored by sequencing all of the nine exons of the CYP2D6 gene. The subject has T188, A1846, T2938, and C4268 (CYP2D6*14) instead of C188, G1846, C2938, and G4268 as in wild-type subjects. XbaI restriction fragment length polymorphism indicated that the subject has a 29-kb allele and a gene deletion (11.5 kb...

Journal: :Human molecular genetics 2014
Danxin Wang Ming J Poi Xiaochun Sun Andrea Gaedigk J Steven Leeder Wolfgang Sadee

Cytochrome P450 2D6 (CYP2D6) is involved in the metabolism of 25% of clinically used drugs. Genetic polymorphisms cause substantial variation in CYP2D6 activity and serve as biomarkers guiding drug therapy. However, genotype-phenotype relationships remain ambiguous except for poor metabolizers carrying null alleles, suggesting the presence of yet unknown genetic variants. Searching for regulato...

2017
Rui Chen Xin Zheng Pei Hu

Purpose: Asian populations have around 40-60% frequency of reduced function allele CYP2D6∗10 compared to 1-2% in Caucasian populations. The wide range of CYP2D6 enzyme activities in subjects with the CYP2D6∗10 variant is a big concern for clinical practice. The quantitative analysis measuring the impact of CYP2D6 enzyme activity as a result of one CYP2D6∗10 allele or two CYP2D6∗10 alleles has n...

2006
Andrea Gaedigk L. DiAnne Bradford Sarah W. Alander J. Steven Leeder

Unexplained cases of CYP2D6 genotype/phenotype discordance continue to be discovered. In previous studies several African Americans with a poor metabolizer phenotype carried the reduced function CYP2D6*10 allele in combination with a nonfunctional allele. We pursued the possibility that these alleles harbor either a known sequence variation (i.e. CYP2D6*36 carrying a gene conversion in exon 9 a...

2011
Rula Y. Qumsieh Bassam R. Ali Yousef M. Abdulrazzaq Ossama Osman Nadia A. Akawi Salim M. A. Bastaki

CYP2D6 belongs to the cytochrome P450 superfamily of enzymes and plays an important role in the metabolism of 20-25% of clinically used drugs including antidepressants. It displays inter-individual and inter-ethnic variability in activity ranging from complete absence to excessive activity which causes adverse drug reactions and toxicity or therapy failure even at normal drug doses. This variab...

Journal: :Journal of clinical pharmacology 2010
Silvana Borges Zeruesenay Desta Yan Jin Azzouz Faouzi Jason D Robarge Sanosh Philips Anne Nguyen Vered Stearns Daniel Hayes James M Rae Todd C Skaar David A Flockhart Lang Li

Accurate assessment of CYP2D6 phenotypes from genotype is inadequate in patients taking CYP2D6 substrate together with CYP2D6 inhibitors. A novel CYP2D6 scoring system is proposed that incorporates the impact of concomitant medications with the genotype in calculating the CYP2D6 activity score. Training (n = 159) and validation (n = 81) data sets were obtained from a prospective cohort tamoxife...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2006
Andrea Gaedigk L Dianne Bradford Sarah W Alander J Steven Leeder

Unexplained cases of CYP2D6 genotype/phenotype discordance continue to be discovered. In previous studies, several African Americans with a poor metabolizer phenotype carried the reduced function CYP2D6*10 allele in combination with a nonfunctional allele. We pursued the possibility that these alleles harbor either a known sequence variation (i.e., CYP2D6*36 carrying a gene conversion in exon 9...

Journal: :Human molecular genetics 2015
Danxin Wang Audrey C Papp Xiaochun Sun

CYP2D6 metabolizes nearly 25% of clinically used drugs. Genetic polymorphisms cause large inter-individual variability in CYP2D6 enzyme activity and are currently used as biomarker to predict CYP2D6 metabolizer phenotype. Previously, we had identified a region 115 kb downstream of CYP2D6 as enhancer for CYP2D6, containing two completely linked single nucleotide polymorphisms (SNPs), rs133333 an...

Journal: :Drug metabolism and pharmacokinetics 2012
Koji Chiba Motohiro Kato Takashi Ito Toshio Suwa Yuichi Sugiyama

Cytochrome P450 2D6 (CYP2D6), which has a large number of genetic polymorphisms, is involved in the metabolism of a wide range of substrates. Dextromethorphan (DM) is a well-known probe drug for CYP2D6 and metabolic ratio (MR) is often used to measure the enzyme activity in vivo. Using the literature values of DM MR, we estimated the inter-individual variability of CYP2D6 hepatic intrinsic clea...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید