نتایج جستجو برای: ctgf

تعداد نتایج: 1816  

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2011
Been-Ren Lin Cheng-Chi Chang Robert Jeen-Chen Chen Yung-Ming Jeng Jin-Tung Liang Po-Huang Lee King-Jen Chang Min-Liang Kuo

PURPOSE Here, we aimed to investigate the role of connective tissue growth factor (CTGF) in peritoneal carcinomatosis (PC) associated with colorectal cancer (CRC) and to characterize the underlying mechanism of CTGF mediating adhesion. EXPERIMENTAL DESIGN A cohort of 136 CRC patient specimens was analyzed in this study. CRC cell lines were used for in vitro adhesion assay and in vivo peritone...

Journal: :Cancer research 2006
Nadja Dornhöfer Suzanne Spong Kevin Bennewith Ali Salim Stephen Klaus Neeraja Kambham Carol Wong Fiona Kaper Patrick Sutphin Randall Nacamuli Michael Höckel Quynh Le Michael Longaker George Yang Albert Koong Amato Giaccia

Pancreatic cancer is highly aggressive and refractory to most existing therapies. Past studies have shown that connective tissue growth factor (CTGF) expression is elevated in human pancreatic adenocarcinomas and some pancreatic cancer cell lines. To address whether and how CTGF influences tumor growth, we generated pancreatic tumor cell lines that overexpress different levels of human CTGF. Th...

Journal: :Diabetes care 2004
David R Hinton Christine Spee Shikun He Stephen Weitz William Usinger Laurie LaBree Noelynn Oliver Jennifer I Lim

OBJECTIVE To evaluate the expression of connective tissue growth factor (CTGF) and its fragments in the vitreous of patients with proliferative diabetic retinopathy (PDR) and to localize CTGF expression in associated preretinal membranes. RESEARCH DESIGN AND METHODS Vitreous was obtained from 24 patients with active PDR, 4 patients with quiescent PDR, and 23 patients with other retinal diseas...

2015
Kimberly G. Riley Raymond C. Pasek Matthew F. Maulis Jennifer Peek Fabrizio Thorel David R. Brigstock Pedro L. Herrera Maureen Gannon

Stimulation of endogenous β-cell expansion could facilitate regeneration in patients with diabetes. In mice, connective tissue growth factor (CTGF) is expressed in embryonic β-cells and in adult β-cells during periods of expansion. We discovered that in embryos CTGF is necessary for β-cell proliferation, and increased CTGF in β-cells promotes proliferation of immature (MafA(-)) insulin-positive...

Journal: :The American journal of physiology 1998
Joseph A Lasky Luis A Ortiz Boihoang Tonthat Gary W Hoyle Miriam Corti Grace Athas Giuseppe Lungarella Arnold Brody Mitchell Friedman

Connective tissue growth factor (CTGF) is a newly described 38-kDa peptide mitogen for fibroblasts and a promoter of connective tissue deposition in the skin. The CTGF gene promotor contains a transforming growth factor-β1 (TGF-β1) response element. Because TGF-β1 expression is upregulated in several models of fibroproliferative lung disease, we asked whether CTGF is also upregulated in a murin...

2015
Fabio A. Mendes Juliana M. Coelho Aguiar Suzana A. Kahn Alice H. Reis Luiz Gustavo Dubois Luciana Ferreira Romão Lais S. S. Ferreira Hervé Chneiweiss Vivaldo Moura Neto José G. Abreu Henning Ulrich

Connective-tissue growth factor (CTGF) is a modular secreted protein implicated in multiple cellular events such as chondrogenesis, skeletogenesis, angiogenesis and wound healing. CTGF contains four different structural modules. This modular organization is characteristic of members of the CCN family. The acronym was derived from the first three members discovered, cysteine-rich 61 (CYR61), CTG...

2005
Jesús Egido Juan Rodriguez-Vita Marta Ruiz-Ortega Mónica Rupérez Vanessa Esteban Elsa Sanchez-López Juan José Plaza

Endothelin (ET)-1 is a potent vasoconstrictor that participates in cardiovascular diseases. Connective tissue growth factor (CTGF) is a novel fibrotic mediator that is overexpressed in human atherosclerotic lesions, myocardial infarction, and experimental models of hypertension. In vascular smooth muscle cells (VSMCs), CTGF regulates cell proliferation/apoptosis, migration, and extracellular ma...

Journal: :The Biochemical journal 2001
N A Wahab N Yevdokimova B S Weston T Roberts X J Li H Brinkman R M Mason

We characterized a rabbit polyclonal antibody raised against human recombinant connective tissue growth factor (CTGF). The antibody recognised a higher molecular mass form (approx. 56 kDa) of CTGF in mesangial cell lysates as well as the monomeric (36-38 kDa) and lower molecular mass forms (<30 kDa) reported previously. Immunohistochemistry detected CTGF protein in glomeruli of kidneys of non-o...

Journal: :Development 2003
Sanja Ivkovic Byeong S Yoon Steven N Popoff Fayez F Safadi Diana E Libuda Robert C Stephenson Aaron Daluiski Karen M Lyons

Coordinated production and remodeling of the extracellular matrix is essential during development. It is of particular importance for skeletogenesis, as the ability of cartilage and bone to provide structural support is determined by the composition and organization of the extracellular matrix. Connective tissue growth factor (CTGF, CCN2) is a secreted protein containing several domains that me...

2012
Roderich Laug Markus Fehrholz Norbert Schütze Boris W. Kramer Vera Krump-Konvalinkova Christian P. Speer Steffen Kunzmann

Connective tissue growth factor (CTGF/CCN2) is an angiogenetic and profibrotic factor, acting downstream of TGF-β, involved in both airway- and vascular remodeling. While the T-helper 1 (Th1) cytokine interferon-gamma (IFN-γ) is well characterized as immune-modulatory and anti-fibrotic cytokine, the role of IFN-γ in lung endothelial cells (LEC) is less defined. Tumour necrosis factor alpha (TNF...

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