objective(s): crocin is a constituent of saffron and has many biological functions. the present study aimed to investigate the effects of intraperitoneal (ip) injection of crocin on sciatic nerve regeneration in male wistar rats. materials and methods: fifty-four rats were divided into 9 groups: groups 1-4 (intact + normal saline and intact + crocin at doses of 5, 20 and 80 mg/kg, respectively)...

a case of soft tissue defect of dorsal hand due to crush injury in a 37-year-old female is reported here. the reconstructive surgery was performed for the hand soft-tissue defect. among different flaps used in the surgery, the regional flap such as radial forearm flap can be done. but usually it is not accepted by patient because of cosmetic appearance. therefore, random pattern abdominal flap ...

background: many people suffer from nerve injury. the time consuming nature of the treatments makes the condition worse. therefore, finding a way to accelerate the process of nerve repair is very important. objective: to determine the effect of ultrasound on the acceleration of crushed peripheral nerve regeneration. methods: the experimental model included crushed rat’s sciatic nerve. 40 rats w...

conclusions a few eligible articles on seismo-nephrology were found in iran, and a limited number of current articles had poor or fair quality. as expected, the chaotic situation after mass disasters and the lack of documentation led to the loss of much important data on the diagnosis and management of victims. lessons learned from the current researches can be used as a valuable guide for futu...

Early inflammatory events may inhibit functional recovery after injury in both the peripheral and central nervous systems. We investigated the role of the inflammatory tumor necrosis factor/nuclear factor-kappaB (NF-kappaB) axis on events subsequent to sciatic nerve crush injury in adult rats. Electrophoretic mobility shift assays revealed that within 6 hours after crush, NF-kappaB DNA-binding ...

An increasing weight of evidence implicates early inflammatory events as inhibitors of functional recovery in both peripheral and central neuropathologies. In this study, we investigated the role of the inflammatory TNF-α/NF-κB axis on events subsequent to sciatic nerve crush injury in rats. Electrophoretic mobility shift assays (EMSA) revealed that within 6 hours post-crush NF-κB DNA binding a...

After direct impact of the trauma, crush syndrome is the second most frequent cause of death after mass disasters. However, since crush syndrome is quite rare in daily practice, mistakes are frequent in the treatment of these cases. This paper summarizes the etiopathogenesis of traumatic rhabdomyolysis and of crush syndrome-based acute kidney injury. The clinical and laboratory features, prophy...

Crush injuries resulting in traumatic rhabdomyolysis are an important cause of acute renal failure. Ischemia reperfusion is the main mechanism of muscle injury. Intravascular volume depletion and renal hypoperfusion, combined with myoglobinuria, result in renal dysfunction. The infusion of intravenous fluids before extrication or soon after injury may lessen the severity of the crush syndrome. ...

Crush injury is a recognised cause of acute renal failure, histologically giving characteristic myoglobin casts in biopsy specimens. A similar syndrome can be precipitated by muscle damage associated with barbiturate overdose1 and carbon monoxide poisoning.2 We report a case of acute renal failure in which the renal biopsy specimen showed a typical "crush injury" appearance due to severe acute ...

OBJECTIVE Crush injury to the sciatic nerve causes oxidative stress. Alfa Lipoic acid (a-LA) is a neuroprotective metabolic antioxidant. This study was designed to investigate the antioxidant effects of pretreatment with a-LA on the crush injury of rat sciatic nerve. METHODS Forty rats were randomized into four groups. Group I and Group II received saline (2 ml, intraperitoneally) and a-LA (1...