To determine the mechanism by which denervation leads to atrophy of skeletal muscle, the fate of previously labeled protein was studied in denervated and contralateral control muscles of hypophysectomized rats. To label muscle proteins, a single injection of aH-leucine was given to the animals 2 days prior to section of the sciatic nerve. On subsequent days, the animals received unlabeled leuci...

To determine the mechanism by which denervation leads to atrophy of skeletal muscle, the fate of previously labeled protein was studied in denervated and contralateral control muscles of hypophysectomized rats. To label muscle proteins, a single injection of aH-leucine was given to the animals 2 days prior to section of the sciatic nerve. On subsequent days, the animals received unlabeled leuci...

1. Liver and serum aspartate aminotransferase (GOT) and alanine aminotransferase (GPT) activities were measured in a hibernating desert lizard, Uromastix hardwickii. The levels of both enzymes were found to be lower in hibernation than during the active period, particularly in the liver. 2. After intramuscular injection of 2 mg of cortisone acetate there was a rapid rise in the levels of these ...

Antibody-dependent cell-mediated cytotoxicity in the Moloney sarcoma virus (MSV) system was evaluated in terms of the differential ability of IgG and IgM from MSV regressor animals to induce cytotoxicity by lymphocytes from lymph node, spleen, and thymus. The cell-mediated cytotoxicity induced by both IgM and IgG was specific for target possessing the appropriate virally determined cell surface...

To determine the mechanism by which denervation leads to atrophy of skeletal muscle, the fate of previously labeled protein was studied in denervated and contralateral control muscles of hypophysectomized rats. To label muscle proteins, a single injection of aH-leucine was given to the animals 2 days prior to section of the sciatic nerve. On subsequent days, the animals received unlabeled leuci...

The administration of cortisone to patients with virilism associated with adrenal hyperplasia results in a marked decrease in urinary 17-ketosteroid excretion (1-3) whereas no significant fall occurs in those patients whose virilism is due to an adrenal tumor (4, 5). The administration of cortisone inhibits pituitary adrenocorticotropin secretion causing secondary atrophy of the adrenals (6, 7)...

Cortisone produces a significant enhancement of infection with MEF1 and Lansing strains of poliomyelitis virus in the Syrian hamster. The enhancement manifests itself in increased severity of symptoms, shortening of the incubation period, marked reduction in survival time and a high mortality rate. The effect of cortisone is protracted, the duration depending on the dose used. There is a recipr...

BACKGROUND Local corticosteroid injection for carpal tunnel syndrome (CTS) provides greater clinical improvement in symptoms one month after injection compared to placebo but significant symptom relief beyond one month has not been demonstrated and the relapse of symptoms is possible.Neuroprotection and myelin repair actions of the progesterone was demonstrated in vivo and in vitro study.We rep...

BACKGROUND Several studies have been performed suggesting that a superolateral approach to cortisone injections for symptomatic osteoarthritis of the knee is more accurate than anteromedial or anterolateral approaches, but there are little data to correlate clinical outcomes with these results. Additionally, there are minimal data to evaluate the pain of such procedures, and this consideration ...