A girl with intractable epilepsy who received high dose valproic acid showed bone marrow suppression, which improved after the end of valproic acid treatment and the administration of supportive treatments. Valproic acid markedly suppressed the in vitro colony growth in this patient. It is believed that high dose valproic acid treatment directly suppressed the growth of haematopoietic progenito...

objective(s): t-cell acute lymphoblastic leukemia (t-all) is an aggressive hematologic malignant tumor. administration of chemical compounds influencing apoptosis and t cell development has been discussed as promising novel therapeutic strategies. valproic acid (vpa) as a recently emerged anti-neoplastic histone deacetylase (hdac) inhibitor and pioglitazone (pgz) as a high-affinity peroxisome p...

objective(s): valproic acid (vpa) has proven to be as one of the most promising useful drug with anticancer properties.in this study, we investigate the vpa effects on e-cadherin expression in hela, tc1, mkn45, and hct116 cell lines.  this study assesses the effects of vpa on human papillomavirus e7 expression in hpv positive cell lines. materials and methods: cell lines were treated by2 mmol/l...

conclusions only a small number of case reports have described valproic acid-induced dress syndrome; therefore, the condition is difficult to prevent. rechallenge with valproic acid should be avoided in patients with a history of reaction to the drug. case presentation we report on the case of a 60-year-old man who had been treated with valproic acid some time before being referred to kowsar ho...

Histone deacetylase inhibitors (HDACi) are a promising class of anticancer agents, yet the specific biological effects resulting in cell death are still poorly understood and clinically relevant markers of response are not adequately defined. The anticonvulsant valproic acid has recently emerged as an HDACi, and in vitro studies suggested that valproic acid may potentiate cytotoxic agents. We e...

Background and Objective: Copper is one of the main micronutrients of body which plays a key role as a cofactor in the function of metabolic enzymes. Previous studies have shown that copper sulfate () inhibits long-term potentiation (LTP) in slices of hippocampal CA1 region. Whereas LTP is involved in learning and epilepsy, it seems that copper effects on LTP could be associated with its effect...

OBJECTIVE To observe clinical and laboratory features of valproic acid-induced hyperammonaemic encephalopathy in patients taking valproic acid. METHODS Observational study was conducted at the Neurology Department, Dow University of Health Sciences, Civil Hospital, Karachi, from February 26, 2010 to March 20, 2011. Ten patients on valproic acid therapy of any age group with idiopathic or seco...

objective(s) the purpose of this study was assessment of the influence of acute manic phase on the steady state pharmacokinetics of valproic acid (vpa) in bipolar patients in comparison with those of epileptic patients. materials and methods ninteen acutely manic and 25 epileptic patients who fulfilled inclusion and exclusion criteria were entered in this prospective study. blood samples were c...

a simple, reproducible and rapid gas chromatographic method for precise determination of valproic acid (vpa) in human plasma has been developed. total time for sample preparation and gc analysis is less than 45 min. after plasma protein precipitation, vpa was extracted into chloroform with suitable recovery. by using stabilwax®-da capillary gc column, a symmetrical gas chromatographic peak was ...

Introduction Valproic acid (Depakine ) is an anti-epileptic drug which is indicated for the treatment of primary generalized epilepsy, partial epilepsy, with focal and psychomotoric symptoms and secondary forms of generalized epilepsia. The mechanism of action of valproic acid has not yet been established, the activity may be related to increased brain concentrations of gamma-aminobutyric acid ...