Rhododendron dauricum L. is an ancient Chinese traditional herb. The pharmacological effects of R. dauricum extract have been shown in chronic tracheitis. The aim of this study was to investigate the cardiovascular effects of Rhododendron dauricum L. flavonoids (RF) on rats and its mechanisms. This study was performed in isolated vascular rings and a rat model of myocardial infarction and isola...

Xia Y, Khalil RA. Sex-related decrease in [Ca ]i signaling and Ca -dependent contraction in inferior vena cava of female rat. Am J Physiol Regul Integr Comp Physiol 298: R15–R24, 2010. First published October 28, 2009; doi:10.1152/ajpregu.00465.2009.—Sex differences in the incidence of varicose veins have been suggested; however, the venous mechanisms involved are unclear. We hypothesized sex-r...

introduction: many reports have shown that the grape (vitis vinifera) seed extract induces antioxidant, hypotensive hypolipidemic, and vasodilatory effects. we have recently shown the relaxatory effect of grape leaf extract on rat's aorta, ileum, uterus and frog's heart rate and contractility. the objective of this study was to investigate the spasmolytic effect of vitis vinifera leaf hydroalco...

background: citrus aurantium is a small citrus tree, with scented white flowers. the c. aurantium is used in asian herbal medicine primarily to treat digestive problems. objective: the goal of this study is to investigate the effect of c. aurantium flower's aqueous extract on uterine contraction in presence of some known uterus stimulants. materials and methods: in experimental study 30 virgin ...

The mechanisms governing vascular smooth muscle tone are incompletely understood. In particular, the role of the sarcolemmal calcium pump PMCA (plasma membrane calmodulin-dependent calcium ATPase), which extrudes Ca2+ from the cytosol, and its importance compared with the sodium/calcium exchanger remain speculative. To test whether the PMCA is a regulator of vascular tone, we generated transgen...

AIM To investigate the effect of pinaverium bromide, a L-type calcium channel blocker with selectivity for the gastrointestinal tract on contractile activity of colonic circular smooth muscle in normal or cold-restraint stressed rats and its possible mechanism. METHODS Cold-restraint stress was conducted on rats to increase fecal pellets output. Each isolated colonic circular muscle strip was...

In this study whether extracellular Ca++ is essential to produce an increase of tension of isolated rat duodenum by ACh, 5-HT, AVP and KCl-, was examined. KCl- and AVP-evoked contractions were almost totally prevented by Ca++ removal from bath solution. The increase of tension of isolated duodenum caused by ACh or 5-HT was totally prevented after adding nifedipine, a Ca++ channel blocker, into ...

it has been reported that rosa damascena hydroalcoholic extract has inhibitory effect at higher concentration but stimulatory action at lower concentrations on ileum. this could be due to the presence of stimulatory components in the extract. r. persica mich. is another species which belongs to rose family but so far there is no report about pharmacological action of its extract. therefore, the...

Sex differences in the incidence of varicose veins have been suggested; however, the venous mechanisms involved are unclear. We hypothesized sex-related differences in venous function and underlying distinctions in intracellular free calcium, [Ca(2+)](i), signaling and Ca(2+)-dependent mechanisms of venous contraction. Circular segments of inferior vena cava (IVC) from male and female Sprague-D...