Beclin 1 participates in development, autophagy, differentiation, anti- apoptosis, neurodegeneration, tumorigenesis and cancer progression. The roles of Beclin 1 in colorectal carcinogenesis and its subsequent progression are still unclear. Here, the mRNA and protein expression of Beclin 1 were determined in colorectal carcinoma and matched mucosa by Reverse transcriptase-polymerase chain react...

Objective: To evaluate epidermal growth factor receptor and Ki-67 immunohistochemical expression in colorectal adenoma carcinoma cases, to relate their with the available clinicopathological data.Methods: The retrospective study was conducted at Faculty of Medicine, Kafrelsheikh University, Egypt, from September 2019 October 2020, comprised formalin-fixed paraffin-embedded specimens related cas...

The link between inflammation and colorectal carcinoma has been acknowledged. However, the impact of bacterial lipopolysaccharide (LPS) binding to Toll-like receptor 4 (TLR4) on chemokine receptors in human colorectal carcinoma cells still remains to be elucidated. The present study shows that exposure to LPS elevated CXC chemokine receptor 7 (CXCR7) expression in colorectal carcinoma SW480 and...

PURPOSE Somatic mutations of the epidermal growth factor receptor (EGFR) gene may predict the sensitivity of non-small cell lung carcinoma to gefitinib. However, no mutations have been reported for colorectal carcinoma. We therefore analyzed EGFR mutations in colorectal adenocarcinomas by the combined use of laser microdissection and sequencing of genomic DNA. EXPERIMENTAL DESIGN We examined ...

Approximately 50% of patients with primary colorectal carcinoma develop liver metastases. This study investigates the possible molecular discrepancies between cancer (pCRC) and their respective

Colorectal carcinoma (CRC) is one of the most common malignant neoplasms with significant morbidity and mortality worldwide. Cancer stem cell hypotheses have gathered attention to their molecular progression. CD44, a marker, reported be more concentrated in premalignant cells. We aimed study prognostic therapeutic utility CD 44 colorectal adenoma low/high-grade dysplasia its correlation clinico...

BACKGROUND Lynch syndrome is the most common form of hereditary colorectal carcinoma. It is characterized by the presence of germline mutations in DNA mismatch repair genes. Mutation carriers have a lifetime risk of developing colorectal carcinoma of approximately 80%. Current treatment guidelines recommend periodic surveillance for colorectal carcinoma in patients with Lynch syndrome. However,...

Hybridoma-derived monoclonal anti-colorectal carcinoma antibodies suppressed the growth of colorectal carcinoma in nude mice as evidenced by a lower incidence of tumors, a longer latency period, and a smaller volume of tumors in antibody-treated than in control animals. The growth-inhibiting properties of monoclonal anti-colorectal antibodies seem to be specific for colorectal carcinoma cells. ...

Colorectal carcinoma is one of the leading causes of death in the elderly. About 20% of patients present with liver metastasis at the time of diagnosis1. The other common metastatic sites of colorectal carcinoma include the lungs, bone and brain2. Splenic metastases from colorectal carcinomas are rare and usually occur in association with other extensive metastasis3. Isolated splenic metastasis...

Cytotoxicity of Lentinus isolates mycelial extracts on human colorectal carcinoma HCT-116 cellsRich Milton R. Dulay, Esperanza C. Cabrera, Sofronio P. Kalaw, Renato G. Reyes, Jerwin Undan