To determine the effect of Artemisia sieberi lotion in signs & symptoms of Tinea versicolor, a randomized, double - blind clinical trial was performed comparing topical application of Artemisia sieberi lotion with Clotrimazole topical lotion, twice daily for 2 week. 60 patients suffering from Tinea versicolor completed the study. 29 patients were treated with Artemisia sieberi lotion and 31 pat...

Clotrimazole (Bay b 5097) is a new synthetic antifungal drug with in vitro activity against Candida spp., Torulopsis glabrata, and Saccharomyces spp. Pharmacological studies in man after the oral administration of 1.5 and 3 g of clotrimazole produced mean peak concentrations in the serum of 1.16 and 1.29 mug/ml, respectively, 2 hr after administration. In six patients taking 1.5 g of clotrimazo...

Clotrimazole is an azole fungicide used as a human pharmaceutical that is known to inhibit cytochrome P450 (CYP) enzymatic activities, including several steroidogenic CYP. In a previous report, we showed that a 7-day exposure to clotrimazole induced the expression of genes related to steroidogenesis in the testes as a compensatory response, involving the activation of the Fsh/Fshr pathway. In t...

The therapeutic efficacy of intermittent, monthly, postmenstrual prophylaxis with a single 500 mg clotrimazole vaginal tablet (n = 33) was compared with placebo tablets (n = 29) in 62 woman (age 28.1, SD 7.2 years) with recurrent vulvovaginal candidiasis. The number of episodes of acute vulvovaginal candidiasis experienced during the year prior to inclusion was 6.3, SD 1.9. The cumulative recur...

background: vulvovaginal candidiasis is one of the most common infections in gynecologic filed, and non–albicans candida species are emerging causative microorganisms. this species shows resistance to routine treatments. one of the suggested treatments is administration of vaginal suppositories of boric acid. the aim of the present study was to compare boric acid with clotrimazole in the treatm...

Background: Vulvovaginal candidiasis is one of the most common infections in gynecologic filed, and non–albicans Candida species are emerging causative microorganisms. This species shows resistance to routine treatments. One of the suggested treatments is administration of vaginal suppositories of boric acid. The aim of the present study was to compare boric acid with clotrimazole in the treatm...

One hundred fifty seven men with candidal balanitis were entered in a randomised, open-label parallel-group multicentre study comparing efficacy and safety of a single oral 150-mg fluconazole-dose with clotrimazole applied topically twice daily for 7 days. Of 64 fluconazole and 68 clotrimazole treated patients who were evaluable at short term follow up, 92% and 91% respectively were clinically ...

BACKGROUND Otomycosis is a common condition affecting external ear and ears with chronic suppurative otitis media, and has a tendency for recurrence. Objective of this study was to determine the efficacy of topical clotrimazole in the treatment of otomycosis. METHODS This descriptive study was conducted at the outpatient department of ENT, Ayub Teaching Hospital Abbottabad, from Jul 2012 to D...

Human lymphocytes were stimulated in vitro by phytohemagglutinin, concanavalin A, pokeweed mitogen, purified protein derivative-tuberculin, and allogenic cells. The deoxyribonucleic acid synthesis of the lymphocytes was inhibited in increasing degree by 4 to 8 mug of amphotericin B per ml of culture irrespective of lymphocyte stimulant used. The effect of clotrimazole on the deoxyribonucleic ac...

To determine the effect of Artemisia sieberi lotion in signs & symptoms of Tinea versicolor, a randomized, double - blind clinical trial was performed comparing topical application of Artemisia sieberi lotion with Clotrimazole topical lotion, twice daily for 2 week. 60 patients suffering from Tinea versicolor completed the study. 29 patients were treated with Artemisia sieberi lotion and 31 pat...