OBJECTIVES This study estimates the proportion of Orphans and Vulnerable Children (OVC) attending school in 89 districts of Uganda from 2011 - 2013 and investigates the factors influencing OVC access to education among this population. METHODS This study used secondary survey data from OVCs aged 5 - 17 years, collected using Lot Quality Assurance Sampling in 87 Ugandan districts over a 3-year...

Epigenetic mechanisms including DNA methylation are supposed to play a key role in fetal development. Here we have investigated fetal DNA-methylation levels of 27,578 CpG loci in 47 chorionic villi (CVS) and 16 amniotic cell (AC) samples. Methylation levels differed significantly between karyotypically normal AC and CVS for 2,014 genes. AC showed more extreme DNA-methylation levels of these gen...

2.4 Invasive Diagnostic Tests .......................... 11 2.4.1 Amniocentesis ............................................. 11 2.4.2 Chorionic Villous Sampling (CVS) ............ 11 2.4.3 Prenatal Maternal Serum Screening ........... 11 2.4.4 Fetal Blood Sampling (FBS)....................... 12 2.4.5 Fetal Surgery ............................................... 12 2.4.6 Genetic Diagnoses .......

This report describes the trends of chorionic villus sampling (CVS) referred for prenatal genetic diagnosis in the past two and a half decades in a Portuguese Center. Our cohort of 491 CVS was mostly performed by the transcervical method at the 12th gestational week. Data collected within the framework of this study relate to the following: sampling method, referral reason versus abnormality an...

OBJECTIVE To describe the outcome of pregnancies with trisomy 2 in cultures of first-trimester chorionic villous samples (CVS) and determine whether amniocentesis is necessary in the management of such cases. METHODS Cultures of chorionic villi were performed at 11-13 weeks in 37 474 pregnancies. In those with trisomy 2 cells, amniocentesis was performed at 16 weeks. Pregnancy outcome was obt...

The pediatrician who cares for a child with a birth defect or genetic disorder may be in the best position to alert the family to the possibility of a recurrence of the same or similar problems in future offspring. The family may wish to know about and may benefit from methods that convert probability statements about recurrence risks into more precise knowledge about a specific abnormality in ...

Objective: To assess the performance of diverse prenatal diagnostic approaches for nuchal translucency (NT) thickening and to investigate optimal screening or action with a NT 95th percentile-3.50 mm. Methods: A retrospective analysis 2,328 pregnancies ≥ percentile through ultrasound-guided transabdominal chorionic villus sampling (CVS), amniocentesis, cordocentesis obtained clinical samples (c...

OBJECTIVE To determine the safety and outcome of transabdominal Chorionic Villus Sampling (CVS) for prenatal diagnosis of genetic disorders. DESIGN Descriptive study. PLACE AND DURATION OF STUDY Department of Pathology, PNS Shifa, Karachi, from January 2003 to December 2004. PATIENTS AND METHODS A total of 143 couples with request for prenatal diagnosis of various genetic disorders were s...