نتایج جستجو برای: cholinergic receptor

تعداد نتایج: 601300  

Journal: :Journal of neurophysiology 2011
Christian Schultheis Martin Brauner Jana F Liewald Alexander Gottschalk

In the nervous system, a perfect balance of excitation and inhibition is required, for example, to enable coordinated locomotion. In Caenorhabditis elegans, cholinergic and GABAergic motor neurons (MNs) effect waves of contralateral muscle contraction and relaxation. Cholinergic MNs innervate muscle as well as GABAergic MNs, projecting to the opposite side of the body, at dyadic synapses. Only ...

کریمیان, سیدمرتضی, دهپور, احمدرضا , پرویز, محسن , کشاورز, منصور ,

In this study the effects of bromocriptine and apomorphine (dopamine receptor agonists) on electrical field induced twitch response of longitudinal muscle of guinea-pig illeum was investigated. Bromocriptine and apomorphine dose dependently inhibited illeal contraction. IC50 for this inhibitory effects were 6.22±0.645×10^-7 M and 5.48±0.647×10^-6 M, respectively. sulpiride (a specific D2 dopami...

Journal: :Biochemical Society transactions 2006
V A Pavlov K J Tracey

Innate immune responses and inflammation are regulated in part by neural mechanisms. In the present paper, we summarize experimental evidence that reveals that innate immunity and inflammation are controlled by the vagus nerve, previously known as a regulator of other vital physiological functions. Activation of vagus nerve cholinergic signalling inhibits TNF (tumour necrosis factor) and other ...

Introduction: Recent findings revealed the biological effects of iron oxide nanoparticles on the central nervous system. Moreover, the brain cholinergic system plays a role in the modulation of anxiety behaviors. Therefore, this study aimed to evaluate the role of dorsal hippocampal muscarinic cholinergic receptors of the CA1 area on anxiety induced by iron oxide nanoparticles in adult male rat...

Journal: :مجله دانشگاه علوم پزشکی کرمانشاه 0
seid- ershad nedaei department of neurosciences, tehran university of medical sciences, iran ali pourmotabbed department of physiology, school of medicine kermanshah university of medical sciences, iran maryam aeenfar student research committee, kermanshah university of medical sciences, iran zahra seifi student research committee, kermanshah university of medical sciences, iran

background: the cholinergic system plays an important role in learning and memory. administration of crocus sativus (saffron) or its constituent, crocin, facilitates the formation of memory. based on above findings, in the current study the effect of crocin in antagonizing retrograde amnesia induced by scopolamine, a cholinergic receptor antagonist, in rats was investigated by using shuttle box...

Journal: :مجله دانشگاه علوم پزشکی کرمانشاه 0
mohammad rasoul ghadami dept. of physiology, school of medicine, kermanshah university of medical sciences, kermanshah ali pourmotab dept. of physiology, school of medicine, kermanshah university of medical sciences, kermanshah niloufar khademi student research committee, kermanshah university of medical sciences, kermanshah

background: the cholinergic system plays an important role in learning and memory. administration of extracts of curcuma longa or its constituent, curcumin, have some roles in cognitive function in animals. the aim of the present study was to investigate the effects of curcumin in preventing spatial performance impairment induced by scopolamine, a cholinergic receptor antagonist, in rats using ...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2008
Matthew A Sullivan Huanmian Chen Hitoshi Morikawa

The striatum plays a central role in sensorimotor learning and action selection. Tonically active cholinergic interneurons in the striatum give rise to dense axonal arborizations and significantly shape striatal output. However, it is not clear how the activity of these neurons is regulated within the striatal microcircuitry. In this study, using rat brain slices, we find that stimulation of in...

2017
R. Chinthu T.R. Anju C.S. Paulose

Many areas of the cerebral cortex process sensory information or coordinate motor output necessary for control of movement. Disturbances in cortical cholinergic system can affect locomotor coordination. Spinal cord injury causes severe motor impairment and disturbances in cholinergic signalling can aggravate the situation. Considering the impact of cortical cholinergic firing in locomotion, we ...

Journal: :British journal of pharmacology 1999
Y C Liu A M Khawaja D F Rogers

1 We investigated whether vasoactive intestinal peptide (VIP) and its related peptides, pituitary adenylate cyclase activating peptide (PACAP) and secretin, regulate cholinergic neural mucus secretion in ferret trachea in vitro, using 35SO4 as a mucus marker. We also studied the interaction between VIP and secretin on cholinergic mucus output. 2 VIP (1 and 10 microM) increased secretion, wherea...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 1999
H Frucht R T Jensen D Dexter W L Yang Y Xiao

We have demonstrated previously cell surface receptors for gastrointestinal peptides on 10 human colon cancer cell lines. Because most of the cells studied bind muscarinic cholinergic agonists, we undertook the determination of the cholinergic receptor subtype expressed by human colon cancer cells, as well as the biological function of these receptors, and more specifically, the effect on cell ...

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