BACKGROUND Intramyocardial injection of skeletal myoblasts (SMB) has been shown to be a promising strategy for treating post-infarction chronic heart failure. However, insufficient therapeutic benefit and occurrence of ventricular arrhythmias are concerns. We hypothesised that the use of a retrograde intracoronary route for SMB-delivery might favourably alter the behaviour of the grafted SMB, c...

background: the intraperitoneal injection is a common method for establishing the experimental animal model infected with parasites. the aim of this study was to investigate if the intraperitoneal injection was another route of trichinella spiralis infection. methods:  from june to july 2015, twenty balb/c mice were intraperitoneally injected with 300 t. spiralis muscle larvae in department of ...

Immunisation experiments are performed on a large scale in laboratory animals e.g. for the production of antibodies. Depending on the immunisation protocol, severe discomfort may be induced. In several countries, guidelines for the immunisation of laboratory animals were drafted to refine immunisation protocols. One of the aspects that effects the immune response as well as the side effects is ...

in recent years, it has become evident that it is necessary to systematically and accurately define particle characteristics in order to understand the potential toxicity of nanoparticles to biological systems. the properties that need to be emphasized are size, shape, dispersion, doping, aggregation, functionalization, physical and chemical properties, surface area, and surface chemistry. rout...

In recent years, it has become evident that it is necessary to systematically and accurately define particle characteristics in order to understand the potential toxicity of nanoparticles to biological systems. The properties that need to be emphasized are size, shape, dispersion, doping, aggregation, functionalization, physical and chemical properties, surface area, and surface chemistry. Rout...

the aim of the present study was to investigate the effect of α2-adrenergic agonist (xylazine) andantagonist (yohimbine) on phasic pain during estrous cycle in female rats. adult female rats weighing 180-220 g were kept under controlled temperature (21-24°c) and light/dark conditions (light on at 6:00 a.m. and light off at 6:00 p.m.). animals were divided into four groups: 1) control group whic...

background: multiple factors have been suggested for prediction of pregnancy in intracytoplasmic sperm injection (icsi) cycles such as the number of injected oocytes, fertilization rate, embryo morphology and quality of transferred embryos. predictive value of these factors is important in icsi outcome. objectives: to evaluate the role of embryo morphology for prediction of pregnancy in icsi cy...

In recent years, it has become evident that it is necessary to systematically and accurately define particle characteristics in order to understand the potential toxicity of nanoparticles to biological systems. The properties that need to be emphasized are size, shape, dispersion, doping, aggregation, functionalization, physical and chemical properties, surface area, and surface chemistry. Rout...

The aim of the present study was to investigate the effect of α2-adrenergic agonist (xylazine) andantagonist (yohimbine) on phasic pain during estrous cycle in female rats. Adult female rats weighing 180-220 g were kept under controlled temperature (21-24°C) and light/dark conditions (light on at 6:00 a.m. and light off at 6:00 p.m.). Animals were divided into four groups: 1) control group whic...

The manner in which a single injection of S. typhosa endotoxin effects the primary hemolysin response to sheep erythrocytes in the mouse has been shown to depend on the dosage, route, and time of administration of the endotoxin, as well as on the route employed for the injection of antigen. The normal production of antibody, following an intravenous or an intraperitoneal injection of red blood ...