cell therapy is known as one of the most promising curative interventions in the spinal cord injury (sci). selection of an appropriate route to transplant the stem cells is very important. principally, four different injection routes have been used in animal experiments. 1. intramedullary route: this route is known as a classic method for transplantation of stem cells. in this method, the stem ...

Background—Therapeutic efficacy of bone marrow (BM) cell injection for treating ischemic chronic heart failure has not been established. In addition, experimental data are lacking on arrhythmia occurrence after BM cell injection. We hypothesized that therapeutic efficacy and arrhythmia occurrence induced by BM cell injection may be affected by the cell delivery route. Methods and Results—Three ...

BACKGROUND Therapeutic efficacy of bone marrow (BM) cell injection for treating ischemic chronic heart failure has not been established. In addition, experimental data are lacking on arrhythmia occurrence after BM cell injection. We hypothesized that therapeutic efficacy and arrhythmia occurrence induced by BM cell injection may be affected by the cell delivery route. METHODS AND RESULTS Thre...

Using single-stranded adeno-associated virus serotype 9 (ssAAV9) vectors containing the neuron-specific synapsin-I promoter, we examined whether different administration routes (direct cerebellar cortical (DC), intrathecal (IT) and intravenous (IV) injections) could elicit specific transduction profiles in the CNS. The DC injection route robustly and exclusively transduced the whole cerebellum,...

Background: Intraosseous injection is a way to administration of drugs. Objective: The clinical comparison of intraosseous and intravenous injection of Thiopental-Na. Methods: First all birds (Twenty six healthy pigeons) were split out into two groups randomly. Group A received 20 mg kg-1 Thiopental-Na by intraosseous rou...

background: recent reports demonstrated that intravenous route as a minimally invasive method, similar to direct injection, is suitable for bone marrow stromal cell (bmsc) transplantation. in this study, we made a comparison of intraspinal and intravenous route of bmsc administration to repair injured spinal cord tissue. methods: six groups of adult female rats were used in this study. laminect...

Background: Different methods have been used for BCG vaccination. Alginate microspheres are useful in delivery of vaccines to the gastrointestinal tract by oral route. Objective: To compare the immune response following oral microencapsulated and subcutaneous (SC) route administration of BCG vaccine in BALB/c mice. Methods: Alginate microspheres were produced by an internal emulsification metho...

background: different methods have been used for bcg vaccination. alginate microspheres are useful in delivery of vaccines to the gastrointestinal tract by oral route. objective: to compare the immune response following oral microencapsulated and subcutaneous (sc) route administration of bcg vaccine in balb/c mice. methods: alginate microspheres were produced by an internal emulsification metho...

Background: Recent reports demonstrated that intravenous route as a minimally invasive method, similar to direct injection, is suitable for bone marrow stromal cell (BMSC) transplantation. In this study, we made a comparison of intraspinal and intravenous route of BMSC administration to repair injured spinal cord tissue. Methods: Six groups of adult female rats were used in this study. Laminect...