Address for Correspondence: Dr. Grace Xu, Department of Medicine, Queen’s University School of Medicine, Kingston, Canada Phone: 647 234 6926 e-mail: [email protected] Received: 31 May 2017 Accepted: 15 September 2017 • DOI: 10.4274/balkanmedj.2017.0621 Available at www.balkanmedicaljournal.org Cite this article as: Xu G, Gottschalk BH, Kocabaş U, Baranchuk A. Not All Brugada Electrocardiogram P...

After its recognition as a distinct clinical entity, Brugada syndrome is increasingly recognized worldwide as an important cause of sudden cardiac death. Brugada syndrome exhibits autosomal dominant inheritance with SCN5A, which encodes the cardiac sodium channel, as the only gene with a proven involvement in 20-30% of patients. Its signature feature is ST segment elevation in right precordial ...

A diagnostic triad characterizes Brugada syndrome. It consists of a right bundle branch block, ST-segment elevation in leads V1-V3 and sudden cardiac death (SCD). Approximately 50% of patients with Brugada syndrome noted to have familial occurrence, this suggests a genetic component of the disease. Mutations in gene SCN5A, an encoder for human cardiac sodium channel on chromosome 3p21, causes B...

Brugada syndrome is characterized by the electrocardiographic (ECG) pattern of right bundle-branch block (RBBB) with a high take-off, coved ST-segment elevation in the precordial leads V1 to V3, and the risk of sudden cardiac death. Typically, there is no evidence of structural heart disease. In many cases, Brugada syndrome has been linked to a mutation of the gene SCN5A, which encodes for the ...

AIMS Brugada syndrome is an inherited sudden-death arrhythmia syndrome. Na(+)-current dysfunction is central, but mutations in the SCN5A gene (encoding the cardiac Na(+)-channel Nav1.5) are present in only 20% of probands. This study addressed the possibility that Brugada patients display specific expression patterns for ion-channels regulating cardiac conduction, excitability, and repolarizati...

AIMS Some patients with idiopathic ventricular fibrillation may suffer from the Brugada syndrome. The diagnostic criteria for the Brugada syndrome are uncertain and arbitrarily set. Therefore, we studied the prevalence of the Brugada syndrome using various diagnostic criteria and long-term follow-up in 37 idiopathic ventricular fibrillation patients. METHODS AND RESULTS Idiopathic ventricular...

The ECG done on his arrival at the emergency room (see questions) shows (i) sinus tachycardia, (ii) a QRS complex that ends with a positive deflection (or prominent J wave) that is, a rsR9 pattern in V1 and V2, and (iii) an elevated downsloping ST segment ending in a small negative T-wave deflection. This ECG pattern in someone with a history of syncopy and documented ventricular fibrillation/a...

The ECG done on his arrival at the emergency room (see questions) shows (i) sinus tachycardia, (ii) a QRS complex that ends with a positive deflection (or prominent J wave) that is, a rsR9 pattern in V1 and V2, and (iii) an elevated downsloping ST segment ending in a small negative T-wave deflection. This ECG pattern in someone with a history of syncopy and documented ventricular fibrillation/a...

Brugada syndrome is an inherited heart disease without structural abnormalities that is thought to arise as a result of accelerated inactivation of Na channels and predominance of transient outward K current to generate a voltage gradient in the right ventricular layers. Brugada syndrome occurs in patients with structurally normal heart and predisposes patients to malignant ventricular arrhythm...

The authors report the case of a 52-year-old woman with depressive syndrome, treated with lamotrigine for about five months, who went to the emergency department for atypical precordial pain. The electrocardiogram (ECG) revealed a 2-mm downsloping ST-segment elevation and negative T waves in V1 and V2. Due to suspicion of ST-elevation acute coronary syndrome, cardiac catheterization was perform...