PURPOSE Cancer-associated retinopathy is a paraneoplastic retinal degeneration which may primarily result from auto-immune mediated apoptosis. It has been hypothesized that high titer of auto-antibodies are able to cross the blood-retinal barrier (BRB) and to enter retinal cells to activate apoptotic pathway which has been already well-established. However, it still remains to be elucidated whe...

This work describes the synthesis, molecular structure, and packaging of compounds 6-bromo-2,3-dimethoxybenzaldehyde (6-BRB) 5-bromo-2,3-dimethoxybenzaldehyde (5-BRB). Characterization in solid-state was carried out by X-ray diffraction, analysis interactions described Hirshfeld surface, which helps understanding effect replacing bromine position aromatic ring. Both (6-BRB 5-BRB) crystallized s...

A diet containing 5% freeze-dried black raspberries (BRB) markedly inhibits esophageal cancer in rats treated with the carcinogen, N-Nitrosomethylbenzylamine (NMBA). We previously identified esophageal genes that become dysregulated after short-term treatment of rats with NMBA and determined which genes are maintained at near-normal levels of expression if the animals were fed 5% BRB prior to a...

Retinal diseases are the main causes of blindness in the Western world. Diabetic retinopathy and age-related macular degeneration continue to increase in prevalence and as main causes of vision loss. Intravitreal anti-VEGF and steroid injections have raised new expectations for their successful treatment. These agents act by stabilizing the blood-retinal barrier (BRB). Our group defined the BRB...

PURPOSE To evaluate the effect of bowel interposition on assessing procedure feasibility, and the usefulness and limiting conditions of bowel displacement techniques in magnetic resonance imaging-guided high-intensity focused ultrasound (MR-HIFU) ablation of uterine fibroids. MATERIALS AND METHODS Institutional review board approved this study. A total of 375 screening MR exams and 206 MR-HIF...

The blood-retinal barrier (BRB) consists of tightly interconnected capillary endothelial cells covered with pericytes and glia, but the role of the pericytes in BRB regulation is not fully understood. Here, we show that platelet-derived growth factor (PDGF)-B/PDGF receptor beta (PDGFRβ) signalling is critical in formation and maturation of BRB through active recruitment of pericytes onto growin...

High-efficiency motors are being gradually introduced in many industrial applications because of their positive impacts on the environment by reducing energy consumption and CO2 emission. In this respect, line start permanent magnet synchronous motors (LS-PMSMs) have been introduced recently. Due to their unique configuration, LS-PMSMs allow the obtaining of super premium efficiency levels, acc...

A belief rule base inference methodology using the evidential reasoning (RIMER) approach has been developed recently. A belief rule base (BRB), which can be treated as a more generalized expert system, extends traditional IF-THEN rules, but requires the assignment of some system parameters including rule weights, attribute weights, and belief degrees. These parameters need to be determined with...

The permeabilities of the blood-retinal (BRB) and blood-brain (BBB) barriers to sucrose were determined simultaneously using an intravenous injection technique in the rat. The method involved direct sampling of retinal tissue in order to avoid errors caused by sucrose penetration across other components of the blood-ocular barrier. The permeability X surface area (PS) product for the BRB was ap...

This paper is devoted to investigating inventory control problems under nonstationary and uncertain demand. A belief-rule-based inventory control (BRB-IC) method is developed, which can be applied in situations where demand and demand-forecast-error (DFE) do not follow certain stochastic distribution and forecasting demand is given in single-point or interval styles. The method can assist decis...