We previously developed SKI-178 (N'-[(1E)-1-(3,4-dimethoxyphenyl)ethylidene]-3-(4-methoxxyphenyl)-1H-pyrazole-5-carbohydrazide) as a novel sphingosine kinase-1 (SphK1) selective inhibitor and, herein, sought to determine the mechanism-of-action of SKI-178-induced cell death. Using human acute myeloid leukemia (AML) cell lines as a model, we present evidence that SKI-178 induces prolonged mitosi...

Materials.. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Parent races true-breeding.. . . . . . . . . . . . . . . . . . . . . . . . . . . Crosses of Gold and Red. . . . . . . . . . . . . . . . . . . . . . . . . . . . . The exceptional female.. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Nondisjunction. . . . . . . . . . . . . . . . . . . . . . ...

Wepreviously developedSKI-178 (N9-[(1E)-1-(3,4-dimethoxyphenyl) ethylidene]-3-(4-methoxxyphenyl)-1H-pyrazole-5-carbohydrazide) as a novel sphingosine kinase-1 (SphK1) selective inhibitor and, herein, sought to determine the mechanism-of-action of SKI178–induced cell death. Using human acute myeloid leukemia (AML) cell lines as a model, we present evidence that SKI-178 induces prolonged mitosis ...

The authors examined racial and gender differences on sport-related sources of acute stress that competitive athletes perceived as highly intense and experienced during the competitive event. Athletes (N = 332, 176 men, 156 women; 59 African Americans: 27 men, 32 women; 232 Caucasians: 125 men, 107 women; and 41 Hispanics: 24 men, 17 women) who competed in sport on a high school or college team...

Background The aim of this survey was to determine the level of awareness and understanding of peer review and peer review models amongst junior hospital doctors and whether this influences clinical decision-making. Methods A 30-question online anonymous survey was developed aimed at determining awareness of peer review models and the purpose of peer review, perceived trustworthiness of diffe...

Objective: To study the trends of socioeconomic inequalities and socioeconomic inequalities in self-perceived health in Spain between 1987 and 2001. Methods: We estimated the distribution of educational level and per capita provincial income, and the differences in lessthan-good self-perceived health by educational level and per capita provincial income in each period. Results: The percentage o...

STUDY DESIGN Self-assembling peptide gel (SPG-178) provides new evidence for the role of a scaffold for treatment of the spinal cord through induction of neuroprotective factors. OBJECTIVE To verify the reproducibility of SPG-178 as scaffold after spinal cord injury, we examine the characteristics of SPG-178 and protective effect on neural cells in vitro and in vivo. SUMMARY OF BACKGROUND D...

Placebo-controlled trials have shown that vitamin C supplementation decreases the duration and severity of common cold infections. However, the magnitude of the benefit has substantially varied, hampering conclusions about the clinical significance of the vitamin. In this paper, 23 studies with regular vitamin C supplementation (>1 g/day) were analyzed to find out factors that may explain some ...