Lactate is the end product of the metabolic process of glucose utilization, known as anaerobic glycolysis, which occurs in the cytoplasm of all cells. In well-oxygenated tissues this lactate is metabolized further, but if tissues are inadequately oxygenated, lactate accumulates locally and blood concentration increases. As a blood marker of tissue hypoxia, lactate measurement has long-establish...

Lactate is the end product of the metabolic process of glucose utilization, known as anaerobic glycolysis, which occurs in the cytosol of all cells. In well-oxygenated tissues this lactate is metabolized further, but if tissues are inadequately oxygenated, lactate accumulates locally and blood concentration rises. As a sensitive but non-specific blood marker of tissue hypoxia, point-ofcare (POC...

The present study investigated the predictive values of urine paraquat (PQ) concentration, dose of poison, arterial blood lactate and Acute Physiology and Chronic Health Evaluation (APACHE) II score in the prognosis of patients with acute PQ poisoning. A total of 194 patients with acute PQ poisoning, hospitalized between April 2012 and January 2014 at the First Affiliated Hospital of P.R. China...

BACKGROUND Using blood lactate monitoring for risk assessment in the critically ill patient remains controversial. Some of the discrepancy is due to uncertainty regarding the appropriate reference interval, and whether to perform a single lactate measurement as a screening method at admission to the hospital, or serial lactate measurements. Furthermore there is no consensus whether the sample s...

The use of central venous oxygen saturation (SvcO2) and arterial lactate in the diagnosis of severe tissue hypoperfusion is well established, and the optimization of these parameters is currently under investigation, particularly in patients with severe sepsis/septic shock. However, the only place for deep venous puncture or the first choice for puncture is often the femoral vein. Although veno...

OBJECTIVE We evaluate the capacity of arterial (ABL), peripheral venous (VBL), and capillary (CBL) blood lactate concentration to early detect the presence of severe sepsis in patients admitted to the emergency department for a septic syndrome. METHODS Patients with signs of sepsis presenting to the emergency department were prospectively enrolled. Blood lactate was measured using a handheld ...

Objective: Fetal scalp lactate has largely replaced pH analysis to assess intrapartum hypoxia. Many obstetrics units use hand-held lactate meters to measure umbilical blood because of its affordability and ease of use. We sought to investigate the agreement of Lactate Pro with a reference method blood gas analyser and to determine its usefulness with a recommended cutoff value of 4.8 mmol/L. Me...

To determine the relation between regional myocardial blood flow, contractile function, and myocardial lactate release during mild-to-moderate regional myocardial ischemia, nine openchest swine were instrumented for measurement of regional myocardial blood flow (microsphere method), contractile function (sonomicrometry), and hemodynamics. L-[1-14C]Lactate or L[U-3C]lactate was infused intraveno...

To determine the relation between regional myocardial blood flow, contractile function, and myocardial lactate release during mild-to-moderate regional myocardial ischemia, nine openchest swine were instrumented for measurement of regional myocardial blood flow (microsphere method), contractile function (sonomicrometry), and hemodynamics. L-[1-14C]Lactate or L[U-3C]lactate was infused intraveno...