declarator, 184, 1224access-specifier, 235, 1226additive-expression, 118, 1217alias-declaration, 140, 1220alignment-specifier, 176, 1223and-expression, 122, 1217asm-definition, 173, 1222assignment-expression, 125, 1218assignment-operator, 125, 1218attribute, 176, 1223attribute-argument-clause, 176, 1223attribute-declaration, 140, 1220attribute-lis...

Cell proliferation is driven by cyclical activation of cyclin-dependent kinases (CDKs), which produce distinct biochemical cell cycle phases. Mitosis (M phase) is orchestrated by CDK-1, complexed with mitotic cyclins. During M phase, chromosomes are segregated by a bipolar array of microtubules called the mitotic spindle. The essential bipolarity of the mitotic spindle is established by the kin...

Abstract With the publication of Diagnostic and Statistical Manual Mental Disorders (DSM-5, APA, 2013), diagnostic criteria for social anxiety disorder (SAD) changed; generalized SAD specifier was removed, a performance-only introduced. Despite growing awareness understanding DSM-5 type specifier, information about its key aspects is lacking. Exploring large, population-based adolescent sample ...

This paper presents first a formal development methodology that enables a specifier to add complexity progressively into the system design, and to formally validate each step wrt client’s requirements. Second, the paper describes the application of this methodology to agent-based systems, as well as development guidelines that help the specifier during the development of such systems. System’s ...

b. Nominative object: AGR P AGR ' s s 6 5 5 5 5 Spec AGR V NP PP s There 3PL are people at the door < LF movement c. Accusative object: AGR P AGR P AGR ' s o o 6 5 5 5 5 5 Spec Spec AGR V NP o John reads a book < LF movement In (1a), the "functional" head AGR enters into a double agreement relation s(ubject) with its specifier: the 0-features of the specifier are copied onto the head, and a Cas...

To assemble mitotic spindles, cells nucleate microtubules from a variety of sources including chromosomes and centrosomes. We know little about how the regulation of microtubule nucleation contributes to spindle bipolarity and spindle size. The Aurora A kinase activator TPX2 is required for microtubule nucleation from chromosomes as well as for spindle bipolarity. We use bacterial artificial ch...

Although centrosomes contribute to spindle formation in most cell types, oocytes of many species are acentrosomal and must organize spindles in their absence. Here we investigate this process in Caenorhabditis elegans, detailing how acentrosomal spindles form and revealing mechanisms required to establish bipolarity. Using high-resolution imaging, we find that in meiosis I, microtubules initial...