AIMS Compared with bare metal stents (BMS), early generation drug-eluting stents (DES) reduce the risk of revascularisation in patients with ST-elevation myocardial infarction (STEMI) at the expense of an increased risk of very late stent thrombosis (ST). Durable polymer coatings for controlled drug release have been identified as a potential trigger for these late adverse events and this has l...

Objective To compare the efficacy and safety of biodegradable polymer drug eluting stents with those of bare metal stents and durable polymer drug eluting stents. Design Mixed treatment comparison meta-analysis of 258 544 patient years of follow-up from randomized trials. Data sources and study selection PubMed, Embase, and Central were searched for randomized trials comparing any of the Food a...

This paper discusses about preparation of biodegradable polymer /clay nanocomposites based on organically modified montmorillonite clay; i.e. cloisite 10A and biodegradable polymer chitosan by solution mixing technique and their characterization. The nanocomposites were successfully prepared and their structures were characterized by powder x-ray diffraction (XRD), particle size analyzer (Beckm...

Two-Year Outcome of a Randomized Trial Comparing Second-Generation Drug-Eluting Stents Using Biodegradable or Durable Polymer Recentnetworkmeta-analyseshave raisedconcerns about the safety of biodegradable polymerdrug-eluting stents (BP-DES) compared with durable polymer everolimus-eluting stents (DP-EES).1-3 The NOBORI Biolimus-Eluting vs XIENCE/ PROMUSEverolimus-ElutingStentTrial (NEXT) is a9...

BACKGROUND Different stents implantation in ST-segment elevation myocardial infarction (STEMI) patients may influence the long term prognosis by affecting vessel healings after stenting. The aim of this study was to evaluate the vessel healings after implantation of drug eluting stents (DES) with biodegradable or durable polymer or of bare-metal stents (BMS) in patients with acute STEMI. METH...

This paper reports microfluidic chip based wet spinning of biodegradable polymers with simple mechanism, and study of cell orientation dependence with fiber size. Biodegradable polymer PLGA fiber was produced by microfluidic chip based spinning device. By controlling feed rate of core polymer and sheath coagulating solutions, we got various PLGA fiber diameter from 10 to 242 μm. L929 mouse fibr...

A rapid, viable and safe fabrication method for biomaterials synthesis is reported using high-frequency AC electrospraying. We demonstrate its potential for polymeric nanoparticle fabrication, drug encapsulation in mono-dispersed micron-sized biodegradable polymer shells and the synthesis of 1microm biodegradable fibers with adjustable pore sizes as bioscaffolds for tissue/orthopaedic engineeri...

Worldwide many researchers are exploring the potential use of biodegradable polymerics as carriers for a wide range of therapeutic applications. In the past two decades, considerable progress has been made in the development of biodegradable polymeric materials, mainly in the biomedical and pharmaceutical industries due to their versatility, biocompatibility and biodegradability properties. The...