In this critical review we review enzymatic systems which involve biocatalytic reactions utilized for information processing (biocomputing). Extensive ongoing research in biocomputing, mimicking Boolean logic gates has been motivated by potential applications in biotechnology and medicine. Furthermore, novel sensor concepts have been contemplated with multiple inputs processed biochemically bef...

A microsize biocomputing system based on enzyme logic processing biochemical signals was developed. Optical transduction of pH signals generated in situ by the enzyme OR logic gate was achieved with the use of a single optode microparticle.

ɗ Reconstruct the structural details of protein complexes that are active in cell adhesion and metabolism. ɗ Predict the consequences of cancer related alterations ; we are focusing on alterations with a compensatory nature ( co-evolutionary related mutations ) as well as those affecting alternative splicing patterns. ɗ Contribute to the analysis of cancer epigenomic and genomic information wit...

Nanoparticles with biocomputing capabilities could potentially be used to create sophisticated robotic devices with a variety of biomedical applications, including intelligent sensors and theranostic agents. DNA/RNA-based computing techniques have already been developed that can offer a complete set of Boolean logic functions and have been used, for example, to analyse cells and deliver molecul...

A new Sense-and-Act system was realized by the integration of a biocomputing system, performing analytical processes, with a signal-responsive electrode. A drug-mimicking release process was triggered by biomolecular signals processed by different logic networks, including three concatenated AND logic gates or a 3-input OR logic gate. Biocatalytically produced NADH, controlled by various combin...

Researchers in the field of biocomputing have, for many years, successfully “harvested and exploited” the natural world for inspiration in developing systems that are robust, adaptable and capable of generating novel and even “creative” solutions to humandefined problems. However, in this position paper we argue that the time has now come for a reassessment of how we exploit biology to generate...

Researchers in the field of biocomputing have, for many years, successfully “harvested and exploited” the natural world for inspiration in developing systems that are robust, adaptable and capable of generating novel and even “creative” solutions to humandefined problems. However, in this position paper we argue that the time has now come for a reassessment of how we exploit biology to generate...

Imaging genomics is an emerging research field, where integrative analysis of imaging and omics data is performed to provide new insights into the phenotypic characteristics and genetic mechanisms of normal and/or disordered biological structures and functions, and to impact the development of new diagnostic, therapeutic and preventive approaches. The Imaging Genomics Session at PSB 2017 aims t...