Herbal medications have a diverse range of active constituents allowing us to use them in variety ways, but are poorly absorbed due their strong polarity and low lipophilicity, resulting bioavailability. The aim this research was improve bioavailability by development in-vitro evaluation phytosomes containing herbal extract Centella asiatica for its antioxidant gastroprotective activity. Phytos...

Abstract The newest method to maintain better bioavailability of antioxidant compounds in the human digestive process is encapsulation using liposomes. liposomes used were lecithin from soybean seeds and L-α-Phosphatidylcholine. Furthermore, curcumin β-carotene encapsulated soy SC-CO2 with 100% ethanol, aquadest 50% v/v ethanol at 50°C, 60°C, 70°C pressure 15 MPa, 20 MPa 25 by ultrasonication f...

The bioavailability of some orally administered botanical extracts is erratic and poor due to limited gastro-intestinal absorption. Bioavailability can be improved by using new delivery systems which can enhance the rate and the extent of solubilization into aqueous intestinal fluids and the capacity to cross biomembranes. Phospholipids based drug delivery system have been found promising for b...

introduction : the encapsulation of nutraceuticals in lipid based carriers, such as liposomes, can lead to increasing of bio-active ingredients bioavailability and controlled release, maintaining their stability in different environmental conditions and increasing solubility of hydrophobic active ingredients in aqueous conditions. food grade liposomes are being increasingly used in food industr...

The target delivery of sensitive components to get the intended benefits is a challenge for global food industry. One principal strategies used boost individualized absorptivity, nutrient stability, and enhanced quality application liposomal systems in industry, which allows controlled release bioactive compounds. Lipid-oriented encapsulation such as liposomes are superior encapsulating compone...

Various phytoconstituents obtained from nature have wide biological activities in chronic diseases and have wide therapeutic efficacy. The main advantage of using phytoconstituents is it provides free from adverse effects treatment where none of the medication can do. However, the physiochemical properties such as poor solubility, poor permeation, and non-targeting at the active site will creat...

Food protein hydrolysates and peptides are considered a category of promising functional food ingredients. However, commercial application of protein hydrolysates and their constituent peptides can be impeded by their low bioavailability, bitter taste, hygroscopicity and likelihood of interacting with the food matrix. Encapsulation as a delivery mechanism can be used to overcome these challenge...

The adequate amount of drug delivery to the brain in neurological patients is a major problem faced by the physicians. Recent studies suggested that intranasal administration of liposomal formulation may improve the drug delivery to the brain. In the present study, an attempt was made to study the brain bioavailability of commonly used anti-Alzheimer drug donepezil (DNP) liposomal formulation b...

The purpose of this study was to optimize a method for the encapsulation of P5 peptide, a new designed peptide containing MHC class I epitopes from rat HER2/neu protein, into liposomes as an approach for breast cancer vaccine formulation. The efficiency of liposomal encapsulation of peptides is generally low and development of an optimized method to increase encapsulation efficiency is a big ch...

materials and methods liposomes were prepared by thin film method using soya lecithin and cholesterol. physicochemical characteristics of the liposomes such as, particle size, drug encapsulation efficiency were determined. also, drug release and in vitro skin permeability through rat skin were evaluated using franz diffusion cells. results the results showed that the maximum drug encapsulation ...