background: caprine besnoitiosis is an economically important disease of goats. neospora caninum, another coccidian parasite of worldwide distribution, infects several animal species and is a major cause of abortion in cattle . combined infections of n. caninum and besnoitia caprae can occur in geo-graphical areas endemic for both species of parasite in goats. this experiment was conducted to i...

conclusions in conclusion, pegfp-kmp-gp96 (fusion) induced th1 platform immune response against leishmania major (mrho/ir/75/er) infection. results according to the results, the level of cytokines interferon-gamma (ifn-γ) and interleukin (il)-4, and ratio of ifn-γ /il4 was changed among different groups of mice before and seven weeks after immunization. the cytokines were increased significantl...

elevated amount of the free radicals due to ionizing radiation causes deteriorating damage on immune system. therefore, we made attempts to investigate the protective effect of vitamin e (vit-e), a biological antioxidant in balb/c mice, so as to find an affordable prophylactic supplementation for individuals who are at risk. several groups of mice were selected and exposed to sub-lethal g -irra...

elevated amounts of free radicals due to ionizing radiation have damaging effects on the body. h2-receptor antagonists have potential oxygen radical scavenging properties. we tried to determine the effects of two h2-receptor antagonists (cimetidine and ranitidine) on lipid peroxidation (lpo) and lipid profile (lp) in plasma and liver of γ-irradiated (1gy/day for 3 days) balb/c mice. the control...

introduction the continuous and rapid growth of telecommunication industries, along with the common application of cell phones, hasraised debates on the associated risks for humanhealth due to exposure to radiofrequency fields, caused bycell phonesorother sources, and industrial and medical applications. accordingly, in this study, we aimed to investigate the effects of cell phone radiation on ...

Evaluation of Anticancer Effect Ginger (Zingiber officinale) and Garlic (Allium sativum) Extracts on Breast Cancer in BALB/c Mice

background: cutaneous leishmaniasis caused by l. major is an important public health problem in endemic areas. the aim of this study was to explore the therapeutic effect of microwave and or infrared radiation in the treatment of lesion induced in balb/c mice by l. major inoculation. methods: the footpad lesion was induced in balb/c mice by inoculation of l. major promastigotes subcutaneously. ...

Introduction: The study aim was to explore a toxicological property and antitumor action of the novel pyridine deriv­ative LHT-17-19 in cell culture on experimental models lung cancer mice.
 Materials methods: performed male female ICR(CD-1), BALB/c, BALB/c nu/nu mice. Pyridine derivative (LHT-17-19) studied as water-soluble pharmaceutical substance. Acute toxicity evaluated groups 5 anima...

Dermokine (DMKN) is a secreted glycoprotein expressed predominantly in the upper epidermis, particularly granular layers, whose expression pattern resembles terminal differentiation molecules. It comprises three splice variants mice and five humans. Our recent investigation generating all isoforms of DMKN deficiency C57BL/6 [DMKN-KO(B6)] demonstrated ichthyosiform skin with transepidermal water...

In Leishmania (L.) major-infected BALB/c mice Th2-type cells results in disease progression, whereas C57BL/6-infected mice mount a Th1-type response, which leads to control of the infection. Th2 response correlates with IgG1 whereas, Th1 response supports switching to IgG2a subclasses. Since IgG isotype-dominated response depends on different CD4 + T cell subsets, we studied the antigenic profi...