نتایج جستجو برای: avian influenza vaccine
تعداد نتایج: 198546 فیلتر نتایج به سال:
BACKGROUND Avian influenza viruses represent a growing threat of an influenza pandemic. The co-circulation of multiple H9N2 genotypes over the past decade has been replaced by one predominant genotype-G57 genotype, which displays a changed antigenicity and improved adaptability in chickens. Effective H9N2 subtype avian influenza virus vaccines for poultry are urgently needed. OBJECTIVE In thi...
INTRODUCTION Recent studies have demonstrated that inactivated seasonal influenza vaccines (IIV) may elicit production of heterosubtypic antibodies, which can neutralize avian H5N1 virus in a small proportion of subjects. We hypothesized that prime boost regimens of live and inactivated trivalent seasonal influenza vaccines (LAIV and IIV) would enhance production of heterosubtypic immunity and ...
Domestic poultry serve as intermediates for transmission of influenza A virus from the wild aquatic bird reservoir to humans, resulting in influenza outbreaks in poultry and potential epidemics/pandemics among human beings. To combat emerging avian influenza virus, an inexpensive, heat-stable, and orally administered influenza vaccine would be useful to vaccinate large commercial poultry flocks...
A cost-effective and efficacious influenza vaccine for use in commercial poultry farms would help protect against avian influenza outbreaks. Current influenza vaccines for poultry are expensive and subtype specific, and therefore there is an urgent need to develop a universal avian influenza vaccine. We have constructed a live bacterial vaccine against avian influenza by expressing a conserved ...
The development of safe and effective vaccines for avian influenza viruses is a priority for pandemic preparedness. Adjuvants improve the efficacy of vaccines and may allow antigen sparing during a pandemic. We have previously shown that influenza virus-like particles (VLPs) comprised of HA, NA, and M1 proteins represent a candidate vaccine for avian influenza H9N2 virus [Pushko P, Tumpey TM, F...
Pandemic influenza has become a high priority item for all public health authorities. An influenza pandemic is believed to be imminent, and scientists agree that it will be a matter of when, where, and what will be the causative agent. Recently, most attention has been directed to human cases of avian influenza caused by a H5N1 avian influenza virus. An effective vaccine will be needed to subst...
Low immunogenicity predicted for emerging avian-origin H7N9 Implication for influenza vaccine design
950 Human Vaccines & Immunotherapeutics Volume 9 Issue 5 *Correspondence to: Anne S. De Groot; Email: [email protected] Submitted: 04/03/13; Revised: 05/03/13; Accepted: 05/04/13 http://dx.doi.org/10.4161/hv.24939 a new avian-origin influenza virus emerged near shanghai in February 2013, and by the beginning of May it had caused over 130 human infections and 36 deaths. Human-to-human transmissi...
The protective efficacy of a subunit avian influenza virus H5 vaccine based on recombinant baculovirus expressed H5 haemagglutinin antigen and an inactivated H5N2 avian influenza vaccine combined with a marker antigen (tetanus toxoid) was compared with commercially available inactivated H5N2 avian influenza vaccine in young ducks. Antibody responses, morbidity, mortality, and virus shedding wer...
Vaccination of poultry is an important control measure for avian influenza employed in the countries where the disease is endemic. We have formulated a coupled ODE-PDE model of avian influenza in domestic birds with imperfect vaccination and age-since-vaccination structure, which includes distinct features of vaccine-induced partial protection. Interestingly, our results show that vaccination c...
The looming influenza virus pandemic requires simple and quicker vaccination strategies to prevent higher mortality and morbidity both in chickens and in humans. The process of current influenza vaccines manufacturing using embryonated eggs cannot help in controlling a future pandemic as it is too slow and the yield obtained by these methods are quit lower. In this study, we have developed a ba...
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