نتایج جستجو برای: apobec3g

تعداد نتایج: 713  

Journal: :South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 2016
K Mhandire K Duri D Mhandire C Musarurwa B Stray-Pedersen C Dandara

BACKGROUND Apolipoprotein B mRNA-editing catalytic polypeptide like-3G (APOBEC3G) is an antiviral enzyme that reduces viral fitness by introducing uracil to thymidine hypermutations in viral genomes. Thus, polymorphisms in the APOBEC3G gene have been implicated in differential outcomes of HIV infection and disease progression. However, there is insufficient evidence on the role of APOBEC3G gene...

2017
Yu Wang Shaofang Wu Siyuan Zheng Shuzhen Wang Arjun Wali Ravesanker Ezhilarasan Erik P. Sulman Dimpy Koul W.K. Alfred Yung

Genomic, transcriptional, and proteomic analyses of brain tumors reveal that subtypes differ in their pathway activity, progression, and response to therapy. We performed an expression profiling of Glioma Initiating Cells (GICs) and comparative analysis between different groups of GICs indicates major variations in gene expression. Hierarchical clustering analysis revealed groups of GICs reflec...

Journal: :PLoS Pathogens 2006
Michael J Wichroski G. Brett Robb Tariq M Rana

APOBEC3G is an antiviral host factor capable of inhibiting the replication of both exogenous and endogenous retroviruses as well as hepatitis B, a DNA virus that replicates through an RNA intermediate. To gain insight into the mechanism whereby APOBEC3G restricts retroviral replication, we investigated the subcellular localization of the protein. Herein, we report that APOBEC3G localizes to mRN...

Journal: :AIDS 2010
Kavidha Reddy Cheryl A Winkler Lise Werner Koleka Mlisana Salim S Abdool Karim Thumbi Ndung'u

OBJECTIVES In the absence of HIV-1 virion infectivity factor (Vif), cellular cytosine deaminases such as apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3G (APOBEC3G) inhibit the virus by inducing hypermutations on viral DNA, among other mechanisms of action. We investigated the association of APOBEC3G mRNA levels and genetic variants on HIV-1 susceptibility, and early disease p...

Journal: :Human molecular genetics 2004
Jianzhi Zhang David M Webb

Human cytidine deaminase APOBEC3G and the virion infectivity factor (vif) of the human immunodeficiency virus (HIV) are a pair of antagonistic molecules. In the absence of vif, APOBEC3G induces a high rate of dC to dU mutations in the nascent reverse transcripts of HIV that leads to the degradation of the HIV genome. HIV vif, on the other hand, can suppress the translation and trigger the degra...

2014
Anjuman Ara Robin P. Love Linda Chelico

The APOBEC3 deoxycytidine deaminase family functions as host restriction factors that can block replication of Vif (virus infectivity factor) deficient HIV-1 virions to differing degrees by deaminating cytosines to uracils in single-stranded (-)HIV-1 DNA. Upon replication of the (-)DNA to (+)DNA, the HIV-1 reverse transcriptase incorporates adenines opposite the uracils, thereby inducing C/G→T/...

Journal: :The journal of medical investigation : JMI 2007
Ahmad Piroozmand Yoshihiko Yamamoto Boonruang Khamsri Mikako Fujita Tsuneo Uchiyama Akio Adachi

We have established a number of 293T cell lines that express a human anti HIV-1 factor APOBEC3G. Out of seven cell clones examined, four were readily demonstrated to express APOBEC3G by immunoblotting analysis. In particular, two clones (A3G-C1 and -C4) were found to produce a much higher level of functional APOBEC3G relative to that by pooled cell clones. The transfection efficiency of all the...

Journal: :Current Biology 2008
Guylaine Haché Keisuke Shindo John S. Albin Reuben S. Harris

The human APOBEC3G protein restricts the replication of Vif-deficient HIV-1 by deaminating nascent viral cDNA cytosines to uracils, leading to viral genomic strand G-to-A hypermutations. However, the HIV-1 Vif protein triggers APOBEC3G degradation, which helps to explain why this innate defense does not protect patients. The APOBEC3G-Vif interaction is a promising therapeutic target, but the be...

2010
Hui Chen Lu-Wen Wang Yan-Qing Huang Zuo-Jiong Gong

To investigate whether the JAK-STAT (Janus kinase-signal transducers and activators of transcription) pathway participates in the regulation of APOBEC3G (Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G) gene transcription and to study the molecular mechanisms of interferon resistance in patients with chronic hepatitis B (CHB), changes in APOBEC3G and STAT-1 expression levels...

Journal: :The Journal of infectious diseases 2007
Mara Biasin Luca Piacentini Sergio Lo Caputo Yasuyoshi Kanari Giuliana Magri Daria Trabattoni Valentina Naddeo Lucia Lopalco Alberto Clivio Eugenio Cesana Francesca Fasano Cristina Bergamaschi Francesco Mazzotta Masaaki Miyazawa Mario Clerici

Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G (APOBEC3G), a human cytidine deaminase, is a potent inhibitor of HIV replication. To explore a possible role of this protein in modulating in vivo susceptibility to HIV infection, we analyzed APOBEC3G expression in HIV-exposed seronegative individuals, HIV-seropositive patients, and healthy control subjects. The results showed ...

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