ntroduction:The emergence and rapid spread of multidrug-resistant Plasmodium strains, especially falciparum, has become a major concern for health professionals when it comes to malaria prophylaxis treatment, limiting medication options, necessitating the search new antimalarial drugs derived from plants. In mice infected with berghei, function Momordica charantia stem crude methanolic extract ...

Background: Combretum nigricans (Combretaceae) is a small, smooth bark tree used in traditional medicine for the treatment of prurigo, dysentery, fever and other symptoms acute malaria North-Central Nigeria. Materials Methods: The antimalarial activity C hydro-methanol crude leaf extract was evaluated against Plasmodium berghei mice. Peters’ 4-day suppressive test early infection Rane’s curativ...

Objective(s): In an attempt to discover new natural active extracts against malaria parasites, the present study evaluated the antiplasmodial properties of selected plants based on Iranian traditional medicine. Materials and Methods: Ten plant species found in Iran were selected and collected based on the available literature about the Iranian traditional medicine. The methanolic extracts of th...

Cassia spectabilis is one of the Indonesian medicinal plants traditionally used to treat different diseases, including malaria. Quality a drug derived from also influenced by quality its raw materials. Thus, in order assure products made plants, it necessary standardize materials and following with antimalarial activity test. The aim this study was C. leaves evaluate activities ethyl acetate ex...

In endemic areas where malaria is prevalent, medicinal plants are often used to treat malaria. This study was conducted to evaluate the in vitro and in vivo antiplasmodial activity and cytotoxicity of extracts of meniran (Phyllanthus niruri L.) herb traditionally used to treat malaria in Indonesia. Three extracts viz aqueous, methanolic and chloroformic extracts were obtained by maceration of t...

Some Dorema species are used in Persian traditional medicine. In the present study the total extract from the roots of Dorema hyrcanum Koso-Pol. was investigated for its in-vitro (pLDH assay) and in-vivo (Peters' 4-days suppressive test) antiplasmodial effects and assessed for cytotoxicity against the normal cell line MDBK (MTT test). The IC50 values for a chloroquine- sensitive (3D7) and a chl...

BACKGROUND The issue of resistance in malarial infection makes development of novel drugs a necessity. An alternative source for discovering such drugs is natural products. Croton macrostachyus H. (Euphorbiaceae) is used in Ethiopian folklore medicine for the treatment of malaria and found to possess antimalarial activity in vitro. However, no further scientific investigations have been carried...

objective: vernonia amygdalina (v.  amygdalina) leaf is locally employed in the southern region of nigeria in the treatment of malari a infection. this study evaluated the in vivo antiplasmodial, antioxidant and immunomodulatory effect of ethanol extract of v.  amygdalina leaf. materials and methods: the active principles of the dried leaf were extracted with ethanol. for quality validation, ch...

OBJECTIVE Zea mays root decoction that has been traditionally used for the treatment of malaria by various tribes in Nigeria, was evaluated for antimalarial potential against malaria parasites using in vivo and in vitro models. MATERIALS AND METHODS The root extract of Zea mays was investigated for antimalarial activity against Plasmodium berghei in mice using rodent malaria models; suppressi...

Malaria, one of the most debilitating diseases, has a huge impact on large populations in tropical and subtropical areas. Albizia adianthifolia is perennial evergreen that thrives moist forest This study intended to assess phytochemical constituents stem bark extract its in-vivo antiplasmodial activity mice infested with Plasmodium berghei. The plant's antimalarial effects at 100, 200 400 mg/kg...