In the present work the pharmacological activities of SFE extracts from T. catharinensis were evaluated. The SFE extracts were obtained using supercritical CO2 plus ethanol as cosolvent (4.6 and 9.2% m/m) at pressures of 250 and 300 bar and temperatures of 35, 45, and 55oC. The crude extracts were solvent-fractionated (hexanic fraction, alkaloid, and aqueous fractions) and analyzed by Thin-laye...

Tuberculosis (TB) is an important disease that causes thousands of deaths around the world. Resistance against antitubercular available drugs has been reported; so, research on new effective antimycobacterial molecules is needed. Antimycobacterial activity of three lignans and two synthetic hydrazones was assessed against Mycobacterium tuberculosis H37Rv by antimycobacterial microdilution assay...

A new series of antimycobacterial agents 2a–j, 3a–d, 6b–f,j, and 7b,f was designed, synthesized and evaluated for antimycobacterial activity against different mycobacterium species i.e. M. tuberculosis, M. avium, and M. intracellulare in an agar dilution method. Some of these compounds (2e, 3a–d) were highly potent with in vitro activity against M. tuberculosis H37Rv and clinical isolates (sens...

recently several 1,3,4-oxadiazole derivatives were identified as potentially active antimycobacterial agents. various 5-aryl-2-thio-1,3,4-oxadiazoles have been reported having good antimycobacterial activity against mycobacterium tuberculosis h37rv (atcc 27294). in this paper we report 3d qsar studies for the 41 molecules of 1,3,4-oxadiazoles by using k-nearest neighbor molecular field analysis...

This article contains data on in vitro antimycobacterial activity and cytotoxicity of hydroethanolic crude extracts from five selected medicinal plant species traditionally used to treat tuberculosis in Ghanaian ethnomedicine, see "Medicinal plants used to treat TB in Ghana" [1]. The interpretation and discussion of these data and further extensive insights into drug discovery against tuberculo...

Recently several 1,3,4-oxadiazole derivatives were identified as potentially active antimycobacterial agents. Various 5-aryl-2-thio-1,3,4-oxadiazoles have been reported having good antimycobacterial activity against Mycobacterium tuberculosis H37Rv (ATCC 27294). In this paper we report 3D QSAR studies for the 41 molecules of 1,3,4-oxadiazoles by using k-Nearest Neighbor Molecular Field Analysis...