The jadomycins are a family of secondary metabolites produced by S. venezuelae ISP5230. Specific jadomycins have been shown to possess a variety of anticancer, antifungal, and antibacterial properties, with different molecular mechanisms of action. Herein we demonstrate qualitative and quantitative direct binding between the validated anticancer target human topoisomerase IIβ and jadomycin DS u...

PcPAF is a novel antifungal protein identified by our recent study, which is produced by a fungal strain Penicillium citrinum W1 isolated from a south-west Indian Ocean sediment sample. The present study identified glycine as a potential metabolite which increased the fungal growth and promoted antifungal activity. Then, GC/MS based metabolomics was used to disclose the metabolic mechanism mani...

Natural products produced by microorganisms are considered an important resource of bioactive secondary metabolites, such as anticancer, antifungal, antibiotic, and immunosuppressive molecules. Streptomyces the richest source natural via possessing a wide number metabolite biosynthetic gene clusters (SM-BGCs). Based on rapid development in sequencing technologies with advances genome mining, ex...

Streptomyces sp. strain SM8, isolated from Haliclona simulans, possesses antifungal and antibacterial activities and inhibits the calcineurin pathway in yeast. The draft genome sequence is 7,145,211 bp, containing 5,929 predicted coding sequences. Several secondary metabolite biosynthetic gene clusters are present, encoding known and novel metabolites, including antimycin.

AIMS To evaluate the antagonistic activity of Fusarium oxysporum nonpathogenic fungal strain S6 against the phytopathogenic fungus Sclerotinia sclerotiorum and to identify the antifungal compounds involved. METHODS AND RESULTS The antagonistic activity of Fusarium oxysporum strain S6 was determined in vitro by dual cultures. The metabolite responsible for the activity was isolated by chromato...

Abstract Since the classic studies of Alexander Flemming, Penicillium strains have been known as a rich source antimicrobial substances. Recent identified novel metabolites produced by sclerotiorum that antibacterial, antifouling and pharmaceutical activities. Here, we report isolation P. (LM 5679) from Amazonian soil carry out culture-based study to determine whether it can produce any seconda...

Nonribosomal peptides, synthesized by nonribosomal peptide synthetases (NRPS), are an important group of diverse bioactive fungal metabolites. Xylaria sp. BCC1067, which is known to produce a variety of biologically active metabolites, was studied for gene encoding NRPS by two different PCR-based methods and seven different NRPS fragments were obtained. In addition, screening a genomic library ...

This study was oriented to production of bioactive tetradecane reported in extracts Pediococcus acidilactici isolated from curd milk and 16S rRNA sequence analysis isolate showed 98% correlation with P. DSM: 20284-CM (accession no. NR042057.1). activity has been tested by disc diffusion assay against Staphylococcus aureus MRSA ATCC 43300, Listeria monocytogenes 19116, Pseudomonas aeruginosa MTC...

During the search for a potent antifungal drug, a cell-permeable metabolite was isolated from a soil isolate taxonomically identified as Penicillium radicum. The strain was found to be a potent antifungal agent. Production conditions of the active compound were optimized and the active compound was isolated, purified, characterized and identified as a phosphoinositide 3-kinase (PI3K) inhibitor,...