COVID-19 is a viral infection and its prevalence requires investigation of different co-morbid conditions including tuberculosis, as well operation temporary infectious diseases hospitals (TIDH) for the treatment deployed on facilities anti-tuberculosis institutions. The objective : analysis follow-up patients with in institutions, assessment impact various medications methods patient lethality...

Tuberculosis is one of the foremost public health problems causing an enormous burden of suffering and deaths. Chemotherapy is the basic approach to clinical tuberculosis control. Essential anti-tuberculosis drugs are Isoniazide (INH), Rifampicin (RMP), Pyrazinamide (PZA), Ethambutol (E) and Streptomycin (S). Department of Pharmacy, KU, KUTH, and Dhulikhel conducted this study in collaboration ...

BACKGROUND Clozapine is the only licensed medication for treatment-resistant schizophrenia. The metabolism of clozapine is affected by multiple pharmacokinetic interactions, so the co-administration of adjunct medications can have a significant clinical effect. The anti- tuberculosis medication rifampicin is a potent inducer of the cytochrome P450 system and therefore can cause a reduction in t...

In the light of three deaths due to liver failure secondary to anti-tuberculosis therapy at the Royal Free Hospital, we have reviewed the current literature, and asked--How common is liver dysfunction with anti-tuberculosis medications and how might it be prevented? Anti-tuberculosis chemotherapy is associated with abnormalities in liver function tests in 10-25% of patients. Clinical hepatitis ...

Mycobacterium tuberculosis (MTB), an acid-fast aerobic bacterium that may grow on gram stain as either a gram-positive or gram-negative bacterium, is the disease-causing agent of (TB). Rifampin, isoniazid, pyrazinamide and ethambutol, first-line anti-tubercular drugs, can all have hepatotoxic side effects. The new medicine needs to work through novel mode action target, be more active than pres...

Tuberculosis is a widespread, infectious disease caused by various strains of mycobacteria, commonly Mycobacterium tuberculosis. not only responsible for an important proportion the global burden disease, but it also contributor to maternal mortality, with being among three leading causes death women aged fifteen forty five years. The main goals tuberculosis treatment are cure patients, prevent...

We evaluated the utility of follow-up interferon-gamma release assays (IGRAs) for the diagnosis of reactivation of latent tuberculosis infection (LTBI) or new tuberculosis in ankylosing spondylitis (AS) patients receiving anti-tumor necrosis factor alpha (anti-TNFα). The study participants (n=127) had a negative IGRA screening before receiving anti-TNFα and were evaluated by follow-up IGRA. We ...

introduction and objectives: tuberculosis (tb) still remains a major health concern both in developing and developed countries. the rate of the liver injury due to anti-tb drugs in developed countries has been reported up to 4%. the goal of this study is to assess the rate and risk factors for anti-tuberculosis drug-induced liver injury (dili). also, a model has been designed to predict dili in...

a 24‑year‑old, unmarried woman diagnosed of pulmonary tuberculosis (ptb) visited our hospital out‑patient department in the month of august‑2013. patient came with the complaint of sever cough with expectoration; evening raise of temperature; gradual loss of appetite and weight since 2‑weeks. we referred the patient to our hospital’s revised national tuberculosis program, direct observed treatm...

Background Multiple sclerosis is an inflammatory and neurodegenerative demyelinating disease. Current treatment of multiple sclerosis focuses on the use of immunomodulatory, immunosuppressant, and selective immunosuppressant agents. Some of these medications may result in high risk of opportunistic infections including tuberculosis. Objective The purpose of this study was to obtain consensus ...