Crude topiramate was prepared from the reaction between diacetonefructopyranose, sulfuric diamide, and 2-picoline. During a controlled processing the presence of Triton-X-100, crude topiramate in a methanol-water solvent, was converted to pure micron size topiramate particles. The factors affecting the purification and micronization of topiramate, such as solvent and anti-solvent type and conce...

Aerosol solvent extraction system (ASES) was used to prepare micro-particle of acetaminophen by supercritical carbon dioxide as an anti-solvent. Experiment was carried out at various temperatures, pressures, solvents and investigated the effects of these parameters on particle size, size distribution and morphology by SEM and laser diffraction particle size analyzer. It seems that the choice of...

Anti-candidal activities of some Myrtus communis L. extracts obtained using accelerated solvent extraction (ASE)Elif Ayse Erdogan, Gulden Goksen, Everest

Abeliophyllum distichum has been demonstrated to possess anticancer, anti-inflammatory, anti-osteoporotic, and anti-obesity effects. However, there is a limitation using this shrub as beneficial material, because had listed endangered. Thus, we established an adventitious root culture of A. (AdAR) overcome limitation. Solvent-solvent partition fractions from methanol extract methyl jasmonate (M...

Currently, scientific publications are focusing on the pharmacological actions of Citrus limon's extract and essential oil. Its oil is rich in bioactive monoterpenoids, such as D-limonene, β-pinene, γ-terpinene. limon oils have been recognized potential source natural insecticides because their selectivity, ability to be biologically degraded into non-toxic compounds, low impacts biodiversity e...

Particle size distribution (PSD) is one of the critical attributes crystals. PSD not only influences downstream processes but also controls final product performance in crystallization. In this work, we have used model system methanol–water-paracetamol for carrying out anti-solvent crystallization to produce paracetamol With reference a base case stirred tank, three devices connected tank with ...

The ionic liquid, N,N,N,N-tetramethylguanidiniumtriflate (TMGTf) was found to be an efficient catalyst solvent for Henry reaction between nitromethane and isatin derivatives to provide 3-hydroxy-3-(nitromethyl)indolin-2-one under mild conditions. The ionic liquid amenable to successive recycling without appreciable decrease in activity. Synthesized compounds have been screened for their anti-di...