The mechanism of anesthesia remains unclear. We do understand, however, that the GABAA receptor, the NMDA receptor, and two-pore-domain K channels are the main targets of anesthetics (Franks, 2008), and several other receptors and ion channels are also influenced in different ways by anesthetics (Alkire et al., 2008). Propofol, barboturates, and volatile anesthetics, all potentiate GABAA recept...

A case is presented in which respiratory distress resulted from the production of methemoglobin Following application of topical benzocaine to a child’s oral mucous membrane. Modern local anesthetics are among the safest of administered agents, with few reported cases of morbidity or mortality. The use of topically applied local anesthetic agents is important in the atraumatic administration of...

background the incidence of transient neurologic symptoms (tns) after spinal anesthesia with lidocaine is reported as high as 40%. objectives this prospective clinical trial was designed to determine the incidence of tns in patients who underwent spinal anesthesia with two different needles, in two different surgical positions. patients and methods the present randomized clinical trial was cond...

allergic reaction to local anesthetics is very rare and most of the reported cases are due to ester local anesthetics. this case presents a parturient who experienced cardiac arrest due to hypersensitivity reaction to lidocaine after epidural injection for cesrarean section.

UNLABELLED Lysophosphatidic acid (LPA) is an intercellular phospholipid mediator with a variety of actions that suggest a role in stimulating inflammatory responses. We therefore studied its actions on neutrophil (PMN) motility and respiratory burst. Because local anesthetics (LA) inhibit LPA signaling and attenuate PMN responses, we also investigated the effects of LA on these actions. Chemota...

The aim of this study was to assess progress in the field of anesthetic drugs over the past 30 years using scientometric indices: popularity indices (general and specific), representing the proportion of articles on a drug relative to all articles in the field of anesthetics (general index) or the subfield of a specific class of anesthetics (specific index); index of change, representing the de...

A significant problem in the dental medicine is pain alleviation. Many studies in the dental anesthesiology result in the production of new agents for locoregional anesthesia. Objective: This article aim to present the results of the last studies on the effect of the local anesthetics used in the oral surgery on patients with cardiovascular diseases. Material: A general review of the existing l...

Nitrous oxide is the most commonly used inhalation anesthetic in dentistry and is commonly used in emergency centers and ambulatory surgery centers as well. When used alone, it is incapable of producing general anesthesia reliably, but it may be combined with other inhalation and/or intravenous agents in deep sedative/general anesthetic techniques. However, as a single agent, it has impressive ...